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11 条记录 (耗时 0.015 秒)

    Pharmaceutical composition which improves in vivo gene transfer
    5.
    发明授权
    Pharmaceutical composition which improves in vivo gene transfer 有权
    改善体内基因转移的药物组合物

    公开(公告)号：US07709452B2

    公开(公告)日：2010-05-04

    申请号：US10502973

    申请日：2003-02-07

    申请人： Bruno Pitard

    发明人： Bruno Pitard

    IPC分类号： A01N43/04 ,  A61K31/70

    CPC分类号： A61K48/0041 ,  A61K31/77 ,  A61K31/785

    摘要： The invention relates to a pharmaceutical composition which combines a tetrafunctional copolymer with a nucleic acid, said copolymer having formula I (namely a poloxamine), and preferably taking the form of one of the cationic mineral or organic salts thereof. The inventive composition can be used to improve in vivo gene transfer.

    摘要翻译： 本发明涉及将四官能共聚物与核酸组合的药物组合物，所述共聚物具有式I（即泊洛沙胺），优选以阳离子矿物质或其有机盐之一的形式。 本发明的组合物可用于改善体内基因转移。

    Pharmaceutical composition which improves in vivo gene transfer
    6.
    发明授权
    Pharmaceutical composition which improves in vivo gene transfer 有权
    改善体内基因转移的药物组合物

    公开(公告)号：US08367631B2

    公开(公告)日：2013-02-05

    申请号：US12659618

    申请日：2010-03-15

    申请人： Bruno Pitard

    发明人： Bruno Pitard

    IPC分类号： A61K48/00 ,  A01N63/00 ,  A01N65/00 ,  C12N5/00 ,  C12N5/02 ,  C07H21/02 ,  C07H21/04

    CPC分类号： A61K48/0041 ,  A61K31/77 ,  A61K31/785

    摘要： A pharmaceutical composition, including at least one nucleic acid, a Tyrode's medium having 140 mM NaC1, 6 mM KC1, 3 mM CaC12, 2 mM MgC12, 10 mM Hepes, pH 7.4, and 10 mM glucose; and a tetrafunctional copolymer of formula (I): where x and y represent, independently of one another, an integer of between 1 and 500, the tetrafunctional copolymer is in a form of a mineral salt wherein said tetrafunctional copolymer is in a cationic form. The compound of formula (I) has a molecular weight of between 1,000 and 25,000 g/mol and an EO/PO ratio of 0.8 to 1.2.

    摘要翻译： 包含至少一种核酸的药物组合物，具有140mM NaCl，6mM KCl，3mM CaCl 2，2mM MgCl 2，10mM Hepes，pH 7.4和10mM葡萄糖的Tyrode's培养基; 和式（I）的四官能共聚物：其中x和y彼此独立地表示1至500的整数，所述四官能共聚物是矿物盐的形式，其中所述四官能共聚物是阳离子形式。 式（I）化合物的分子量为1,000〜25,000g / mol，EO / PO比为0.8〜1.2。

    NOVEL MULTIMODULAR ASSEMBLY USEFUL FOR INTRACELLULAR DELIVERY
    7.
    发明申请
    NOVEL MULTIMODULAR ASSEMBLY USEFUL FOR INTRACELLULAR DELIVERY 有权
    新颖的多功能组件可用于细胞内输送

    公开(公告)号：US20120058139A1

    公开(公告)日：2012-03-08

    申请号：US13062339

    申请日：2009-09-02

    申请人： Bruno Pitard ,  Charles Tellier ,  Corinne Miral ,  Emilie Letrou-Bonneval

    发明人： Bruno Pitard ,  Charles Tellier ,  Corinne Miral ,  Emilie Letrou-Bonneval

    IPC分类号： A61K39/385 ,  A61P43/00 ,  A61P37/04 ,  C12N15/63 ,  A61K48/00

    CPC分类号： A61K48/0041 ,  A61K9/1272 ,  A61K9/1273 ,  A61K47/6911

    摘要： A stabilized multimodular assembly for intracellular delivery comprising a complex of at least one cationic transfection agent and of at least one negatively charged macromolecule, wherein the complex has a theoretical charge ratio ranging from about 0 to about 4, and an efficient amount of at least one amphiphilic block co-polymer acting as a steric colloidal stabilizer with respect to the complex, the block co-polymer having hydrophilic and hydrophobic blocks wherein at least one hydrophilic block is conjugated with at least one targeting ligand.

    摘要翻译： 一种用于细胞内递送的稳定的多模式组合物，其包含至少一种阳离子转染剂和至少一个带负电荷的大分子的复合物，其中所述络合物具有约0至约4的理论电荷比，以及有效量的至少一种 作为相对于配合物的空间胶体稳定剂的两亲嵌段共聚物，嵌段共聚物具有亲水和疏水嵌段，其中至少一个亲水嵌段与至少一个靶向配体缀合。

    Pharmaceutical composition which improves in vivo gene transfer
    8.
    发明申请
    Pharmaceutical composition which improves in vivo gene transfer 有权
    改善体内基因转移的药物组合物

    公开(公告)号：US20100179212A1

    公开(公告)日：2010-07-15

    申请号：US12659618

    申请日：2010-03-15

    申请人： Bruno Pitard

    发明人： Bruno Pitard

    IPC分类号： A61K31/713 ,  A61K31/7088 ,  A61P21/00 ,  A61P9/00

    CPC分类号： A61K48/0041 ,  A61K31/77 ,  A61K31/785

    摘要： A pharmaceutical composition which combines a tetrafunctional copolymer with a nucleic acid, said copolymer having formula I (namely a poloxamine), and preferably taking the form of one of the cationic mineral or organic salts thereof. The composition can be used to improve in vivo gene transfer.

    摘要翻译： 将四官能共聚物与核酸组合的药物组合物，所述具有式I的共聚物（即泊洛沙胺），优选以阳离子矿物质或其有机盐之一的形式。 该组合物可用于改善体内基因转移。

    Multimodular assembly useful for intracellular delivery
    10.
    发明授权
    Multimodular assembly useful for intracellular delivery 有权
    用于细胞内递送的多模式组装

    公开(公告)号：US08790664B2

    公开(公告)日：2014-07-29

    申请号：US13062339

    申请日：2009-09-02

    申请人： Bruno Pitard ,  Charles Tellier ,  Corinne Miral ,  Emilie Letrou-Bonneval

    发明人： Bruno Pitard ,  Charles Tellier ,  Corinne Miral ,  Emilie Letrou-Bonneval

    IPC分类号： A61K48/00

    CPC分类号： A61K48/0041 ,  A61K9/1272 ,  A61K9/1273 ,  A61K47/6911

    摘要： A stabilized multimodular assembly for intracellular delivery comprising a complex of at least one cationic transfection agent and of at least one negatively charged macromolecule, wherein the complex has a theoretical charge ratio ranging from about 0 to about 4, and an efficient amount of at least one amphiphilic block co-polymer acting as a steric colloidal stabilizer with respect to the complex, the block co-polymer having hydrophilic and hydrophobic blocks wherein at least one hydrophilic block is conjugated with at least one targeting ligand.

    摘要翻译： 一种用于细胞内递送的稳定的多模式组合物，其包含至少一种阳离子转染剂和至少一个带负电荷的大分子的复合物，其中所述络合物具有约0至约4的理论电荷比，以及有效量的至少一种 作为相对于配合物的空间胶体稳定剂的两亲嵌段共聚物，嵌段共聚物具有亲水和疏水嵌段，其中至少一个亲水嵌段与至少一个靶向配体缀合。