发明授权
US06897322B2 Method of producing 1-alkyl-3-aryl-5-difluoromethoxy-1H-pyrazoles
失效
1-烷基-3-芳基-5-二氟甲氧基-1H-吡唑的制备方法
- 专利标题： Method of producing 1-alkyl-3-aryl-5-difluoromethoxy-1H-pyrazoles
- 专利标题（中）： 1-烷基-3-芳基-5-二氟甲氧基-1H-吡唑的制备方法
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申请号： US10250503申请日： 2002-01-15
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公开(公告)号： US06897322B2公开(公告)日： 2005-05-24
- 发明人: Thorsten Volk , Michael Puhl , Cyrill Zagar , Rene Lochtman , Norbert Götz , Gerhard Hamprecht
- 申请人： Thorsten Volk , Michael Puhl , Cyrill Zagar , Rene Lochtman , Norbert Götz , Gerhard Hamprecht
- 申请人地址： DE Ludwigshafen
- 专利权人： BASF Aktiengesellschaft
- 当前专利权人： BASF Aktiengesellschaft
- 当前专利权人地址： DE Ludwigshafen
- 代理机构： Novak Druce & Quigg, LLP
- 优先权： DE10101762 20010116
- 国际申请： PCTEP02/00347 WO 20020115
- 国际公布： WO0205550 WO 20020718
- 主分类号： C07D231/20
- IPC分类号： C07D231/20 ; C07D231/14
摘要：
The invention relates to a method of preparing 1-alkyl-3-aryl-5-difluoromethoxy-1H-pyrazoles of the formula (I), wherein aryl represents a mono- or polysubstituted phenyl ring, and R1 represents C1-C4 alkyl. The inventive method is characterized by reacting, in a first reaction step, a β-ketoester of the general formula (II) with hydrazine and by successively reacting the reaction product obtained with chlorodifluoromethane and a compound R1-L, wherein R1 has the meanings indicated above and L represents the leaving group of a nucleophilic displacement reaction.