发明授权
US06906105B2 Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states
失效
查耳酮及其类似物作为抑制血管生成和相关疾病状态的药剂
- 专利标题： Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states
- 专利标题（中）： 查耳酮及其类似物作为抑制血管生成和相关疾病状态的药剂
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申请号： US10198786申请日： 2002-07-18
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公开(公告)号： US06906105B2公开(公告)日： 2005-06-14
- 发明人: J. Phillip Bowen , Thomas Philip Robinson , Tedman Ehlers , David Goldsmith , Jack Arbiser
- 申请人： J. Phillip Bowen , Thomas Philip Robinson , Tedman Ehlers , David Goldsmith , Jack Arbiser
- 代理商 Henry D. Coleman; R. Neil Sudol; William J. Sapone
- 主分类号： A61P17/00
- IPC分类号： A61P17/00 ; A61P35/00 ; C07C49/217 ; C07C49/223 ; C07C49/233 ; C07C49/235 ; C07C49/683 ; C07C49/697 ; C07C49/782 ; C07C49/796 ; C07C49/813 ; C07C49/84 ; C07D207/32 ; C07D207/333 ; C07D213/50 ; C07D307/46 ; A61K31/12 ; C07C49/213
摘要：
The present invention relates to chalcone and chalcone derivatives and analogs which are useful as angiogenesis inhibitors. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good activity as angiogenesis inhibitors. The present invention also relates to the use of chalcone and its analogs as antitumor/anticancer agents and to treat a number of conditions or disease states in which angiogenesis is a factor, including angiongenic skin diseases such as psoriasis, acne, rosacea, warts, eczema, hemangiomas, lymphangiogenesis, among numerous others, as well as chronic inflammatory disease such as arthritis.
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