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1.发明申请Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states 失效查耳酮及其类似物作为抑制血管生成和相关疾病状态的药剂公开(公告)号：US20090018167A1
公开(公告)日：2009-01-15
申请号：US12229340
申请日：2008-08-22
IPC分类号： A61K31/444 , C07C49/76 , C07D311/04 , C07D307/30 , C07D213/44 , A61K31/44 , A61P25/02 , A61P19/02 , A61P17/10 , C07D211/82 , A61K31/12 , A61K31/352 , A61K31/341
CPC分类号： C07D207/333 , C07C49/217 , C07C49/223 , C07C49/233 , C07C49/235 , C07C49/683 , C07C49/697 , C07C49/782 , C07C49/796 , C07C49/813 , C07C49/84 , C07D213/50 , C07D307/46
摘要： The present invention relates to chalcone and chalcone derivatives and analogs which are useful as angiogenesis inhibitors. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good activity as angiogenesis inhibitors. The present invention also relates to the use of chalcone and its analogs as antitumor/anticancer agents and to treat a number of conditions or disease states in which angiogenesis is a factor, including angiogenic skin diseases such as psoriasis, acne, rosacea, warts, eczema, hemangiomas, lymphangiogenesis, among numerous others, as well as chronic inflammatory disease such as arthritis.
摘要翻译： 本发明涉及可用作血管发生抑制剂的查耳酮和查耳酮衍生物和类似物。 合成成本低的本发明化合物作为血管生成抑制剂表现出意想不到的良好活性。 本发明还涉及查耳酮及其类似物作为抗肿瘤/抗癌剂并用于治疗血管生成是其中一个因素的一些病症或疾病状态，包括血管生成皮肤疾病如牛皮癣，痤疮，酒渣鼻，疣，湿疹 ，血管瘤，淋巴管生成等等，以及慢性炎性疾病如关节炎。
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2.发明授权Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states 失效查耳酮及其类似物作为抑制血管生成和相关疾病状态的药剂公开(公告)号：US07872029B2
公开(公告)日：2011-01-18
申请号：US12229340
申请日：2008-08-22
IPC分类号： C07D213/02 , A61K31/44
CPC分类号： C07D207/333 , C07C49/217 , C07C49/223 , C07C49/233 , C07C49/235 , C07C49/683 , C07C49/697 , C07C49/782 , C07C49/796 , C07C49/813 , C07C49/84 , C07D213/50 , C07D307/46
摘要： The present invention relates to chalcone and chalcone derivatives and analogs which are useful as angiogenesis inhibitors. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good activity as angiogenesis inhibitors. The present invention also relates to the use of chalcone and its analogs as antitumor/anticancer agents and to treat a number of conditions or disease states in which angiogenesis is a factor, including angiogenic skin diseases such as psoriasis, acne, rosacea, warts, eczema, hemangiomas, lymphangiogenesis, among numerous others, as well as chronic inflammatory disease such as arthritis.
摘要翻译： 本发明涉及可用作血管发生抑制剂的查耳酮和查耳酮衍生物和类似物。 合成成本低的本发明化合物作为血管生成抑制剂表现出意想不到的良好活性。 本发明还涉及查耳酮及其类似物作为抗肿瘤/抗癌剂并用于治疗血管生成是其中一个因素的一些病症或疾病状态，包括血管生成皮肤疾病如牛皮癣，痤疮，酒渣鼻，疣，湿疹 ，血管瘤，淋巴管生成等等，以及慢性炎性疾病如关节炎。
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3.发明授权Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states 失效查耳酮及其类似物作为抑制血管生成和相关疾病状态的药剂公开(公告)号：US07432303B2
公开(公告)日：2008-10-07
申请号：US11074545
申请日：2005-03-08
IPC分类号： C07C49/11 , C07C49/115 , A61K31/12
CPC分类号： C07D207/333 , C07C49/217 , C07C49/223 , C07C49/233 , C07C49/235 , C07C49/683 , C07C49/697 , C07C49/782 , C07C49/796 , C07C49/813 , C07C49/84 , C07D213/50 , C07D307/46
摘要： The present invention relates to chalcone and chalcone derivatives and analogs which are useful as angiogenesis inhibitors. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good activity as angiogenesis inhibitors. The present invention also relates to the use of chalcone and its analogs as antitumor/anticancer agents and to treat a number of conditions or disease states in which angiogenesis is a factor, including angiongenic skin diseases such as psoriasis, acne, rosacea, warts, eczema, hemangiomas, lymphangiogenesis, among numerous others, as well as chronic inflammatory disease such as arthritis.
摘要翻译： 本发明涉及可用作血管发生抑制剂的查耳酮和查耳酮衍生物和类似物。 合成成本低的本发明化合物作为血管生成抑制剂表现出意想不到的良好活性。 本发明还涉及查耳酮及其类似物作为抗肿瘤/抗癌剂并用于治疗血管生成是其中一个因素的许多病症或疾病状态，包括银屑病，痤疮，酒渣鼻，疣，湿疹 ，血管瘤，淋巴管生成等等，以及慢性炎性疾病如关节炎。
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4.发明授权Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states 失效查耳酮及其类似物作为抑制血管生成和相关疾病状态的药剂公开(公告)号：US06906105B2
公开(公告)日：2005-06-14
申请号：US10198786
申请日：2002-07-18
IPC分类号： A61P17/00 , A61P35/00 , C07C49/217 , C07C49/223 , C07C49/233 , C07C49/235 , C07C49/683 , C07C49/697 , C07C49/782 , C07C49/796 , C07C49/813 , C07C49/84 , C07D207/32 , C07D207/333 , C07D213/50 , C07D307/46 , A61K31/12 , C07C49/213
CPC分类号： C07D207/333 , C07C49/217 , C07C49/223 , C07C49/233 , C07C49/235 , C07C49/683 , C07C49/697 , C07C49/782 , C07C49/796 , C07C49/813 , C07C49/84 , C07D213/50 , C07D307/46
摘要： The present invention relates to chalcone and chalcone derivatives and analogs which are useful as angiogenesis inhibitors. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good activity as angiogenesis inhibitors. The present invention also relates to the use of chalcone and its analogs as antitumor/anticancer agents and to treat a number of conditions or disease states in which angiogenesis is a factor, including angiongenic skin diseases such as psoriasis, acne, rosacea, warts, eczema, hemangiomas, lymphangiogenesis, among numerous others, as well as chronic inflammatory disease such as arthritis.
摘要翻译： 本发明涉及可用作血管发生抑制剂的查耳酮和查耳酮衍生物和类似物。 合成成本低的本发明化合物作为血管生成抑制剂表现出意想不到的良好活性。 本发明还涉及查耳酮及其类似物作为抗肿瘤/抗癌剂并用于治疗血管生成是其中一个因素的许多病症或疾病状态，包括银屑病，痤疮，酒渣鼻，疣，湿疹 ，血管瘤，淋巴管生成等等，以及慢性炎性疾病如关节炎。
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5.发明授权Chalcone and its analogs as agents for the inhibition of angiogensis and related disease states 失效查耳酮及其类似物作为抑制血管生成和相关疾病状态的药剂公开(公告)号：US06462075B1
公开(公告)日：2002-10-08
申请号：US09748599
申请日：2000-12-26
IPC分类号： C07D31100
CPC分类号： C07D207/333 , C07C49/217 , C07C49/223 , C07C49/233 , C07C49/235 , C07C49/683 , C07C49/697 , C07C49/782 , C07C49/796 , C07C49/813 , C07C49/84 , C07D213/50 , C07D307/46
摘要： The present invention relates to chalcone and chalcone derivatives and analogs which are useful as angiogenesis inhibitors. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good activity as angiogenesis inhibitors. The present invention also relates to the use of chalcone and its analogs as antitumor/anticancer agents and to treat a number of conditions or disease states in which angiogenesis is a factor, incluidng angiongenic skin diseases such as psoriasis, acne, rosacea, warts, eczema, hemangiomas, lymphangiogenesis, among numerous others, as well as chronic inflammatory disease such as arthritis.
摘要翻译： 本发明涉及可用作血管发生抑制剂的查耳酮和查耳酮衍生物和类似物。 合成成本低的本发明化合物作为血管生成抑制剂表现出意想不到的良好活性。 本发明还涉及查耳酮及其类似物作为抗肿瘤/抗癌剂并用于治疗血管发生是一个因素的许多病症或疾病状态，包括血管性皮肤疾病如银屑病，痤疮，酒渣鼻，疣，湿疹 ，血管瘤，淋巴管生成等等，以及慢性炎性疾病如关节炎。
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6.发明申请Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states 失效查耳酮及其类似物作为抑制血管生成和相关疾病状态的药剂公开(公告)号：US20050148599A1
公开(公告)日：2005-07-07
申请号：US11074545
申请日：2005-03-08
申请人： J. Bowen , Thomas Robinson , Tedman Ehlers , David Goldsmith , Jack Arbiser
发明人： J. Bowen , Thomas Robinson , Tedman Ehlers , David Goldsmith , Jack Arbiser
IPC分类号： A61P17/00 , A61P35/00 , C07C49/217 , C07C49/223 , C07C49/233 , C07C49/235 , C07C49/683 , C07C49/697 , C07C49/782 , C07C49/796 , C07C49/813 , C07C49/84 , C07D207/32 , C07D207/333 , C07D213/50 , C07D307/46 , A61K31/4965 , A61K31/12 , A61K31/192 , A61K31/40 , A61K31/444 , A61K31/47
CPC分类号： C07D207/333 , C07C49/217 , C07C49/223 , C07C49/233 , C07C49/235 , C07C49/683 , C07C49/697 , C07C49/782 , C07C49/796 , C07C49/813 , C07C49/84 , C07D213/50 , C07D307/46
摘要： The present invention relates to chalcone and chalcone derivatives and analogs which are useful as angiogenesis inhibitors. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good activity as angiogenesis inhibitors. The present invention also relates to the use of chalcone and its analogs as antitumor/anticancer agents and to treat a number of conditions or disease states in which angiogenesis is a factor, incluidng angiongenic skin diseases such as psoriasis, acne, rosacea, warts, eczema, hemangiomas, lymphangiogenesis, among numerous others, as well as chronic inflammatory disease such as arthritis.
摘要翻译： 本发明涉及可用作血管发生抑制剂的查耳酮和查耳酮衍生物和类似物。 合成成本低的本发明化合物作为血管生成抑制剂表现出意想不到的良好活性。 本发明还涉及查耳酮及其类似物作为抗肿瘤/抗癌剂并用于治疗血管发生是一个因素的许多病症或疾病状态，包括血管性皮肤疾病如银屑病，痤疮，酒渣鼻，疣，湿疹 ，血管瘤，淋巴管生成等等，以及慢性炎性疾病如关节炎。
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