- 专利标题： Metal complexes that contain perfluoroalkyl, process for their production and their use in NMR diagnosis
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申请号： US10197421申请日： 2002-07-18
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公开(公告)号： US06916461B2公开(公告)日： 2005-07-12
- 发明人: Johannes Platzek , Ulrich Niedballa , Bernd Radüchel , Wolfgang Schlecker , Hanns-Joachim Weinmann , Thomas Frenzel , Bernd Misselwitz , Wolfgang Ebert
- 申请人： Johannes Platzek , Ulrich Niedballa , Bernd Radüchel , Wolfgang Schlecker , Hanns-Joachim Weinmann , Thomas Frenzel , Bernd Misselwitz , Wolfgang Ebert
- 申请人地址： DE Berlin
- 专利权人： Schering AG
- 当前专利权人： Schering AG
- 当前专利权人地址： DE Berlin
- 代理机构： Millen White Zelano & Branigan, P.C.
- 优先权： DE19603033 19960119
- 主分类号： C07D295/22
- IPC分类号： C07D295/22 ; A61K49/00 ; A61K49/10 ; A61P35/00 ; A61P43/00 ; B65D25/16 ; B65D47/08 ; B65D83/00 ; C07C229/16 ; C07C229/22 ; C07C229/76 ; C07C235/10 ; C07C237/08 ; C07C237/10 ; C07C311/05 ; C07C311/06 ; C07D257/02 ; C07D295/26 ; C07F5/00 ; C07F13/00 ; A61B5/055 ; A61K51/00
摘要：
The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy.The compounds according to the invention are suitable especially as in vivo contrast media in nuclear spin tomography (MRT). They can preferably be used as blood-pool agents and as lymphographic agents.
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