发明授权
- 专利标题: Antagonists of melanin concentrating hormone receptor
- 专利标题(中): 黑色素浓缩激素受体的拮抗剂
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申请号: US10459682申请日: 2003-06-11
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公开(公告)号: US06921821B2公开(公告)日: 2005-07-26
- 发明人: Christopher Blackburn , Su-Jen Lai , Jennifer L. Che , Martin P. Maguire , Michael A. Patane , Matthew J. LaMarche , Courtney A. Cullis , James Brown , Anil Vasudevan , Jennifer C. Freeman , Mathew M. Mulhern , John K. Lynch , Ju Gao , Dariusz Wodka , Andrew J. Souers , Rajesh Iyengar , Mary Katherin Verzal , Philip R. Kym
- 申请人: Christopher Blackburn , Su-Jen Lai , Jennifer L. Che , Martin P. Maguire , Michael A. Patane , Matthew J. LaMarche , Courtney A. Cullis , James Brown , Anil Vasudevan , Jennifer C. Freeman , Mathew M. Mulhern , John K. Lynch , Ju Gao , Dariusz Wodka , Andrew J. Souers , Rajesh Iyengar , Mary Katherin Verzal , Philip R. Kym
- 申请人地址: US IL Abbott Park
- 专利权人: Abbott Laboratories
- 当前专利权人: Abbott Laboratories
- 当前专利权人地址: US IL Abbott Park
- 代理商 Johanna M. Corbin; Cheryl L. Becker
- 主分类号: C07D403/14
- IPC分类号: C07D403/14 ; A61K31/453 ; A61K31/4535 ; A61K31/454 ; A61K31/4709 ; A61K31/496 ; A61K31/517 ; A61P3/04 ; A61P3/06 ; A61P3/10 ; A61P5/00 ; A61P15/00 ; A61P25/08 ; A61P25/14 ; A61P25/16 ; A61P25/18 ; A61P25/22 ; A61P25/24 ; A61P25/28 ; A61P43/00 ; C07D401/14 ; C07D405/12 ; C07D405/14 ; C07D409/14 ; C07D413/14 ; C07D417/14 ; C07D451/04 ; C07D205/08 ; C07D239/02 ; C07D401/00
摘要:
This invention provides compounds that are antagonists of melanin concentrating hormone receptor-1 (MCH-R1). The compounds are represented by formula I: where m is zero or one, n is zero to two, Y is oxygen or —N(R9)—, R1, R2, R3, R4, R5, R9 and Ring A are defined in the specification. Coumarin and quinolone compounds where R1 and R2 together form a fused benzo ring are preferred. The invention also provides compounds of formula VI where the coumarin moiety is replaced by a quinazolinone ring. The compounds are useful for treating MCH-R1-related disorders, particularly overweight conditions including obesity.
公开/授权文献
- US20040106645A1 Antagonists of melanin concentrating hormone receptor 公开/授权日:2004-06-03
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