发明授权
US06926894B2 Composition exhibiting a von willebrand factor (vWF) protease activity comprising a polypeptide chain with the amino acid sequence AAGGILHLELLV
有权
表现出von Willebrand因子(vWF)蛋白酶活性的组合物,其包含具有氨基酸序列AAGGILHLELLV的多肽链
- 专利标题: Composition exhibiting a von willebrand factor (vWF) protease activity comprising a polypeptide chain with the amino acid sequence AAGGILHLELLV
- 专利标题(中): 表现出von Willebrand因子(vWF)蛋白酶活性的组合物,其包含具有氨基酸序列AAGGILHLELLV的多肽链
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申请号: US09833328申请日: 2001-04-12
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公开(公告)号: US06926894B2公开(公告)日: 2005-08-09
- 发明人: Bernhard Laemmle , Helena Elisabeth Gerritsen , Miha Furlan , Peter Turecek , Hans-Peter Schwarz , Friedrich Scheiflinger , Gerhard Antoine , Randolf Kerschbaumer , Luigina Tagliavacca , Klaus Zimmermann
- 申请人: Bernhard Laemmle , Helena Elisabeth Gerritsen , Miha Furlan , Peter Turecek , Hans-Peter Schwarz , Friedrich Scheiflinger , Gerhard Antoine , Randolf Kerschbaumer , Luigina Tagliavacca , Klaus Zimmermann
- 申请人地址: AT Vienna
- 专利权人: Baxter Aktiengesellschaft
- 当前专利权人: Baxter Aktiengesellschaft
- 当前专利权人地址: AT Vienna
- 代理机构: Townsend and Townsend and Crew LLP
- 主分类号: A61K38/00
- IPC分类号: A61K38/00 ; C07K16/36 ; C12N9/64 ; C12N15/57 ; A61K35/14 ; A61K38/46 ; C07H21/04
摘要:
The invention relates to vWF cleaving entities having a molecular weight of 180 kD, 170 kD, 160 kD, 120 kD or 110 kD and an N-terminal amino acid sequence of AAGGILHLELLV (SEQ ID NO: 1), vWF cleaving complexes and methods for their production.
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