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1.发明授权公开(公告)号：US08425947B2
公开(公告)日：2013-04-23
申请号：US13021551
申请日：2011-02-04
申请人： Heinz Redl , Johann Eibl , Irmgard Schlag
发明人： Heinz Redl , Guenther Schlag , Johann Eibl
IPC分类号： A01N65/00
CPC分类号： A61L24/106
摘要： The present invention provides a fibrinogen-based tissue adhesive which contains an elastase inhibitor.
摘要翻译： 本发明提供含有弹性蛋白酶抑制剂的纤维蛋白原组织粘合剂。
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2.发明申请RECOMBINANT CELL CLONES HAVING INCREASED STABILITY AND METHODS OF MAKING AND USING SAME 审中-公开具有增加的稳定性的重组细胞克隆及其制备和使用方法公开(公告)号：US20090258391A1
公开(公告)日：2009-10-15
申请号：US12488441
申请日：2009-06-19
申请人： Manfred Reiter , Wolfgang Mundt , Friedrich Dorner
发明人： Manfred Reiter , Wolfgang Mundt , Friedrich Dorner
CPC分类号： C12N5/0075 , C12N5/0043 , C12N2500/32 , C12N2500/38 , C12N2500/46 , C12N2500/50 , C12N2500/76 , C12N2531/00
摘要： Disclosed are a stable recombinant cell clones which are stable in serum- and protein-free medium for at least 40 generations, a biomass obtained by multiplying the stable cell clone under serum- and protein-free culturing conditions, and a method of preparing recombinant proteins by means of the biomass. Furthermore, the invention relates to a method of recovering stable recombinant cell clones.
摘要翻译： 公开了稳定的重组细胞克隆，其在无血清和无蛋白质的培养基中稳定至少40代，通过在无血清和无蛋白质培养条件下倍增稳定细胞克隆获得的生物质，以及制备重组蛋白质的方法 通过生物量。 此外，本发明涉及一种回收稳定的重组细胞克隆的方法。
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3.发明授权公开(公告)号：US07459295B2
公开(公告)日：2008-12-02
申请号：US11443925
申请日：2006-05-30
申请人： Heinz Redl , Gunther Schlag , Johann Eibl
发明人： Heinz Redl , Gunther Schlag , Johann Eibl
IPC分类号： C12N9/00
CPC分类号： A61L24/106
摘要： The present invention provides a fibrinogen-based tissue adhesive which contains an elastase inhibitor.
摘要翻译： 本发明提供含有弹性蛋白酶抑制剂的纤维蛋白原组织粘合剂。
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公开(公告)号：US07091325B2
公开(公告)日：2006-08-15
申请号：US10749832
申请日：2003-12-30
申请人： Heinz Redl , Walter Fuerst , Rudolf Kneidinger , Sam L. Helgerson , Douglas Looker , Elisabeth M. Inman , Jane P. Richards , Catalina Wong
发明人： Heinz Redl , Walter Fuerst , Rudolf Kneidinger , Sam L. Helgerson , Douglas Looker , Elisabeth M. Inman , Jane P. Richards , Catalina Wong
IPC分类号： A61K31/7088 , A61K38/17 , A61K39/395 , C07H21/00 , C07K14/435
CPC分类号： C07K14/745 , A61K38/00 , A61K47/64 , A61K47/6435 , A61K47/665 , B82Y5/00
摘要： A fibrin/fibrinogen binding conjugate for forming a depot for the sustained release of a pharmaceutically active substance from a fibrin clot. The conjugate comprises a fibrin/fibrinogen binding moiety bound to a pharmaceutically active substance either directly or via an intervening substance capturing moiety such as an antibody. The conjugate can also be a recombinant fusion protein comprising a fibrin/fibrinogen binding moiety such as VEGF165 C-terminal domain fused to a wound-healing substance such as leptin.
摘要翻译： 用于形成用于从血纤维蛋白凝块中持续释放药物活性物质的贮库的纤维蛋白/纤维蛋白原结合缀合物。 缀合物包含直接或通过介入物质捕获部分如抗体与药物活性物质结合的纤维蛋白/纤维蛋白原结合部分。 缀合物还可以是包含纤维蛋白/纤维蛋白原结合部分的重组融合蛋白，例如融合到伤口愈合物质如瘦蛋白的VEGF 165 C末端结构域。
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公开(公告)号：US06958322B1
公开(公告)日：2005-10-25
申请号：US09632722
申请日：2000-08-04
申请人： Michele Himmelspach , Uwe Schlokat
发明人： Michele Himmelspach , Uwe Schlokat
CPC分类号： C12N9/6432 , C12Y304/21006
摘要： This invention describes a factor Xa analog which has a substitution of a minimum of one of the amino acid between Glu226 and Arg234 and possibly Ile235, relative to the amino acid numbering according to FIG. 1, a preparation containing the activated form of the factor X analog, and a method for the production of these molecules.
摘要翻译： 本发明描述了相对于根据图1的氨基酸编号，具有至少一个氨基酸在Glu226和Arg234之间以及可能的Ile235的取代的因子Xa类似物。 1，含有因子X类似物的活化形式的制剂，以及这些分子的制备方法。
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公开(公告)号：US06953837B2
公开(公告)日：2005-10-11
申请号：US10003621
申请日：2001-11-02
申请人： Artur Mitterer , Bernhard Fischer , Öyvind L. Schönberger , Kathrin Thomas-Urban , Friedrich Dorner , Johann Eibl
发明人： Artur Mitterer , Bernhard Fischer , Öyvind L. Schönberger , Kathrin Thomas-Urban , Friedrich Dorner , Johann Eibl
CPC分类号： A61K38/37 , C07K14/755
摘要： There is disclosed a method of recovering factor VIII/vWF-complex which is characterized in that factor VIII/vWF-complex from a protein solution is bound to a cation exchanger and is recovered by step-wise elution of factor VIII/vWF-complex, which particularly contains high-molecular vWF multimers, as well as a factor VIII/vWF-complex obtainable by means of cation exchange chromatography.
摘要翻译： 公开了一种回收因子VIII / vWF-复合物的方法，其特征在于将来自蛋白质溶液的因子VIII / vWF-复合物结合到阳离子交换剂并通过逐步洗脱因子VIII / vWF-复合物来回收， 其特别包含高分子vWF多聚体，以及通过阳离子交换层析可获得的因子VIII / vWF-络合物。
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公开(公告)号：US20050209154A1
公开(公告)日：2005-09-22
申请号：US11132326
申请日：2005-05-19
IPC分类号： A61K38/43 , A61K31/00 , A61K38/37 , A61P7/00 , A61P7/04 , C07K1/18 , C07K1/22 , C07K14/745 , C07K14/755
CPC分类号： C07K14/755 , Y10S514/834 , Y10T436/25375
摘要： There are disclosed a stable factor VIII/vWF-complex, particularly comprising high-molecular vWF multimers, being free from low-molecular vWF molecules and from proteolytic vWF degradation products, as well as a method of producing this complex.
摘要翻译： 公开了稳定的因子VIII / vWF-复合物，特别是包含不含低分子vWF分子和蛋白水解vWF降解产物的高分子vWF多聚体，以及生产该复合物的方法。
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8.发明申请Recombinant cell clones having increased stability and methods of making and using the same 有权具有增加的稳定性的重组细胞克隆及其制备和使用方法公开(公告)号：US20050196843A1
公开(公告)日：2005-09-08
申请号：US11123362
申请日：2005-05-06
申请人： Manfred Reiter , Wolfgang Mundt , Friedrich Dorner
发明人： Manfred Reiter , Wolfgang Mundt , Friedrich Dorner
IPC分类号： C12N5/00 , C12N5/08 , C12N5/06 , C07H21/04 , C07K14/755
CPC分类号： C12N5/0075 , C12N5/0043 , C12N2500/32 , C12N2500/38 , C12N2500/46 , C12N2500/50 , C12N2500/76 , C12N2531/00
摘要： Disclosed are a stable recombinant cell clones which are stable in serum- and protein-free medium for at least 40 generations, a biomass obtained by multiplying the stable cell clone under serum- and protein-free culturing conditions, and a method of preparing recombinant proteins by means of the biomass. Furthermore, the invention relates to a method of recovering stable recombinant cell clones.
摘要翻译： 公开了稳定的重组细胞克隆，其在无血清和无蛋白质的培养基中稳定至少40代，通过在无血清和无蛋白质培养条件下倍增稳定细胞克隆获得的生物质，以及制备重组蛋白质的方法 通过生物量。 此外，本发明涉及一种回收稳定的重组细胞克隆的方法。
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公开(公告)号：US20050074836A1
公开(公告)日：2005-04-07
申请号：US09831679
申请日：2001-05-10
申请人： Petrus Lenting , Jan Van Mourik , Koenraad Mertens , Hans Pannekoek , Peter Turecek , Hans-Peter Schwarz , Friedrich Scheiflinger
发明人： Petrus Lenting , Jan Van Mourik , Koenraad Mertens , Hans Pannekoek , Peter Turecek , Hans-Peter Schwarz , Friedrich Scheiflinger
IPC分类号： A61K38/00 , A61K38/37 , C07K14/705 , C07K14/755 , C12N15/12 , C12P21/02 , C07H21/04 , C07K14/775 , C12N5/06
CPC分类号： C07K14/755 , A61K38/00 , A61K38/37 , C07K14/705 , A61K2300/00
摘要： Factor VIII polypeptides having FVIII:C activity that contain modifications in the A3 and/or C1 and/or C2 domains of the sequence of the light chain of Factor VIII, characterized by the binding affinity to low density lipoprotein receptor protein, and methods for producing the same.
摘要翻译： 具有FVIII：C活性的因子VIII多肽，其含有因子VIII轻链序列的A3和/或C1和/或C2结构域的修饰，其特征在于与低密度脂蛋白受体蛋白的结合亲和力，以及生产方法 一样。
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公开(公告)号：US6156888A
公开(公告)日：2000-12-05
申请号：US324934
申请日：1999-06-03
申请人： Johannes J. Voorberg
发明人： Johannes J. Voorberg
IPC分类号： G01N33/68 , A61K38/00 , A61K38/43 , A61K38/55 , C07K14/755 , C07K14/81 , C07K14/815 , C07K16/36 , C07K19/00 , C12N5/10 , C12N15/02 , C12N15/09 , C12P21/08 , G01N33/86 , C07H21/02 , A01N43/04 , C07H21/04
CPC分类号： C07K14/755 , C07K14/8121 , C07K14/815 , A61K38/00 , C07K2319/00 , Y10S514/834 , Y10S930/10
摘要： Hybrid proteins which affect blood coagulation comprise a region from a donor anticoagulant or antithrombotic protein, and the resulting hybrid protein has a modified biological activity. Information concerning the hybrid proteins implicates DNA sequences encoding the proteins and hosts, including transgenic animals, that possess these DNA sequences; antibodies directed against hybrid proteins; methods of modifying the properties of proteins; and treatment methods employing hybrid proteins.
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