发明授权
- 专利标题： Expansion of hematopoietic cells using midkine or pleiotrophin
- 专利标题（中）： 使用中期因子或多余营养素扩大造血细胞
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申请号： US10071039申请日： 2002-02-08
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公开(公告)号： US06939669B2公开(公告)日： 2005-09-06
- 发明人: Makoto Kikuchi , Shinya Ikematsu , Munehiro Oda , Sadatoshi Sakuma , Takashi Muramatsu
- 申请人： Makoto Kikuchi , Shinya Ikematsu , Munehiro Oda , Sadatoshi Sakuma , Takashi Muramatsu
- 申请人地址： JP Tokyo
- 专利权人： Meiji Dairies Corporation
- 当前专利权人： Meiji Dairies Corporation
- 当前专利权人地址： JP Tokyo
- 代理机构： Fish & Richardson P.C.
- 优先权： JP8-198531 19960710
- 主分类号： A61K35/28
- IPC分类号： A61K35/28 ; A61K38/18 ; A61K38/19 ; A61K38/20 ; C12N5/0789 ; C12N5/00 ; C07K14/475 ; C07K14/52
摘要：
The present invention provides novel use of the MK family that is used alone as an agent for proliferating hematopoietic stem cells and hematopoietic precursor cells. The invention also provides an agent for remarkably enhancing the above-described effect for promoting the proliferation of hematopoietic stem cells and hematopoietic precursor cells, comprising the MK family in combination with known hematopoietic factors such as IL-3, IL-6, G-CSF, GM-CSF, M-CSF, SCF, and EPO.
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