发明授权
- 专利标题： Substituted piperidines, medicaments containing these compounds, and methods for the production thereof
- 专利标题（中）： 取代的哌啶，含有这些化合物的药物及其制备方法
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申请号： US10169009申请日： 2000-12-22
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公开(公告)号： US06949541B2公开(公告)日： 2005-09-27
- 发明人: Klaus Rudolf , Henri Doods , Eckhart Bauer , Rudolf Hurnaus , Wolfgang Eberlein , Alexander Dreyer , Stephan Georg Mueller
- 申请人： Klaus Rudolf , Henri Doods , Eckhart Bauer , Rudolf Hurnaus , Wolfgang Eberlein , Alexander Dreyer , Stephan Georg Mueller
- 申请人地址： DE Ingelheim
- 专利权人： Boehringer Ingelheim Pharma KG
- 当前专利权人： Boehringer Ingelheim Pharma KG
- 当前专利权人地址： DE Ingelheim
- 代理商 Michael M. Morris; Mary-Ellen M. Devlin; Alan R. Stempel
- 优先权： DE19963868 19991230
- 国际申请： PCT/EP00/13236 WO 20001222
- 国际公布： WO01/49676 WO 20010712
- 主分类号： A61K31/4745
- IPC分类号： A61K31/4745 ; A61K31/496 ; A61K31/517 ; A61K31/5377 ; A61K31/5513 ; A61P11/06 ; A61P15/12 ; A61P17/00 ; A61P25/04 ; A61P25/36 ; A61P29/00 ; A61P37/08 ; A61P43/00 ; C07D401/04 ; C07D401/14 ; C07D405/14 ; C07D471/04 ; A61K31/445 ; A61K38/04 ; A61P25/06
摘要：
The present invention relates to substituted piperidines of general formula wherein A1, A2, R, R1 and R2 are defined as in claim 1, the tautomers, the diastereomers, the enantiomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable pharmacological properties, particularly CGRP-antagonistic properties, pharmaceutical compositions containing these compounds, their use and processes for preparing them.
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