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公开(公告)号：US20090137621A1
公开(公告)日：2009-05-28
申请号：US12248574
申请日：2008-10-09
CPC分类号： A61K9/0075 , A61K9/4816 , A61K9/4858 , A61K31/451 , A61K31/4523 , A61M11/003 , A61M15/0028 , A61M15/0033 , A61M2202/064
摘要： The invention relates to capsules for inhalation (inhalettes) made from specific capsule materials with a reduced moisture content, which contain the active substance tiotropium in the form of powdered preparations and are characterised by increased stability.
摘要翻译： 本发明涉及由具有降低的水分含量的特定胶囊材料制成的用于吸入（吸入剂）的胶囊，其含有粉末制剂形式的活性物质噻托溴铵，其特征在于增加的稳定性。
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2.发明授权Carboxylic acid amides, the preparation thereof and their use as pharmaceutical compositions 有权羧酸酰胺，其制备及其作为药物组合物的用途公开(公告)号：US07425641B2
公开(公告)日：2008-09-16
申请号：US10938804
申请日：2004-09-10
申请人： Uwe Ries , Henning Priepke , Armin Heckel , Herbert Nar , Wolfgang Wienen , Jean Marie Stassen
发明人： Uwe Ries , Henning Priepke , Armin Heckel , Herbert Nar , Wolfgang Wienen , Jean Marie Stassen
IPC分类号： C07D272/02 , C07D211/06 , A61K31/40 , A61K31/445
CPC分类号： C07D295/185 , C07C257/18 , C07C311/21 , C07C311/46 , C07C2601/08 , C07D207/12 , C07D211/46 , C07D213/68 , C07D295/135 , C07D295/192
摘要： The present invention relates to carboxylic acid amides of general formula wherein R1 to R5, Ar, m and n are defined as in claim 1, the tautomers, stereoisomers, mixtures thereof, the prodrugs and the salts thereof which have valuable properties. The compounds of the above general formula I wherein R5 denotes a cyano group are valuable intermediate products for preparing the other compounds of general formula I, and the compounds of the above general formula I wherein R5 denotes one of the amidino groups mentioned in claim 1 have valuable pharmacological properties, particularly an antithrombotic activity and a factor Xa-inhibiting activity.
摘要翻译： 本发明涉及通式其中R 1至R 5，Ar，m和n如权利要求1所定义的羧酸酰胺，互变异构体，立体异构体，混合物 其前体药物及其盐具有有价值的性质。 其中R 5表示氰基的上述通式I的化合物是制备其它通式I化合物的有价值的中间产物，以及上述通式I的化合物，其中R 1， 5 表示权利要求1中提及的脒基之一具有有价值的药理学性质，特别是抗血栓形成活性和因子Xa抑制活性。
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公开(公告)号：US20060292084A1
公开(公告)日：2006-12-28
申请号：US11462797
申请日：2006-08-07
CPC分类号： A61K9/4883 , A61J3/074 , A61K9/0075 , A61K9/48 , Y10T137/085
摘要： A process which can be used in the laboratory or on an industrial scale for cleaning the inner wall of hard gelatine capsules, in which the sealed capsules are cleaned with a powder formulation.
摘要翻译： 可在实验室或工业规模中用于清洁硬明胶胶囊的内壁的方法，其中用粉末制剂清洁密封的胶囊。
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4.发明授权公开(公告)号：US07151103B2
公开(公告)日：2006-12-19
申请号：US10272603
申请日：2002-10-16
IPC分类号： A61K31/496 , A61K31/497
CPC分类号： A61K31/496
摘要： The invention relates to the use of flibanserin, or a pharmaceutically acceptable acid addition salt thereof, for the treatment of disorders of sexual desire.
摘要翻译： 本发明涉及氟班色林或其药学上可接受的酸加成盐在治疗性欲障碍中的用途。
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公开(公告)号：US20060276526A1
公开(公告)日：2006-12-07
申请号：US11462531
申请日：2006-08-04
申请人： Kai Donsbach , Irmgard Hof
发明人： Kai Donsbach , Irmgard Hof
IPC分类号： A61K31/4184 , C07D403/02
CPC分类号： C07D235/20
摘要： The invention relates to a crystalline sodium salt of 4′-[2-n-propyl-4-methyl-6-(1-methyl-benzimidazol-2-yl)benzimidazol-1-ylmethyl]biphenyl-2-carboxylic acid (INN: telmisartan), processes for preparing it and the use thereof for preparing a pharmaceutical composition.
摘要翻译： 本发明涉及4' - [2-正丙基-4-甲基-6-（1-甲基 - 苯并咪唑-2-基）苯并咪唑-1-基甲基]联苯-2-羧酸（INN）的结晶钠盐 ：替米沙坦），其制备方法及其用于制备药物组合物的用途。
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公开(公告)号：US07070800B2
公开(公告)日：2006-07-04
申请号：US09975418
申请日：2001-10-11
CPC分类号： A61K9/0075 , A61K9/14 , A61K31/439
摘要： The invention relates to powdered preparations containing tiotropium for inhalation, processes for preparing them as well as their use in preparing a pharmaceutical composition for the treatment of respiratory complaints, particularly for the treatment of COPD (chronic obstructive pulmonary disease) and asthma.
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7.发明授权Substituted aryl and heteroaryl derivatives, the preparation thereof and the use therof as pharmaceutical compositions 有权取代的芳基和杂芳基衍生物，其制备方法和用作药物组合物公开(公告)号：US07005437B2
公开(公告)日：2006-02-28
申请号：US10142699
申请日：2002-05-10
申请人： Henning Priepke , Uwe Ries , Herbert Nar , Wolfgang Wienen , Jean-Marie Stassen
发明人： Henning Priepke , Uwe Ries , Herbert Nar , Wolfgang Wienen , Jean-Marie Stassen
IPC分类号： A61K31/445 , A61K31/44 , A61K31/40 , C07D301/00 , C07D211/68
CPC分类号： C07D295/185 , C07C257/18 , C07C311/37 , C07C2601/08 , C07D207/20 , C07D295/192
摘要： The present invention relates to new substituted aryl and heteroaryl derivatives of general formula wherein A, Ar, n, X, Y1, Y2, Y3, Y4, R1 and R5 are defined as in claim 1, the prodrugs, the tautomers, stereoisomers, mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable properties. Thus, the compounds of the above general formula I wherein R5 does not contain a cyano group have, in particular, an antithrombotic effect and a selective factor Xa-inhibiting effect with generally improved compatibility. The compounds of the above general formula I wherein R5 contains a cyano group are valuable intermediate products for preparing the antithrombotic compounds of general formula I.
摘要翻译： 本发明涉及通式为“化学式id =”CHEM-US-00001“num =”000的新的取代的芳基和杂芳基衍生物
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公开(公告)号：US20060039868A1
公开(公告)日：2006-02-23
申请号：US11254573
申请日：2005-10-20
IPC分类号： A61L9/04 , A61K9/14 , A61K31/4745
CPC分类号： A61K9/0075 , A61K9/14 , A61K31/439
摘要： The invention relates to powdered preparations containing tiotropium for inhalation, processes for preparing them as well as their use in preparing a pharmaceutical composition for the treatment of respiratory complaints, particularly for the treatment of COPD (chronic obstructive pulmonary disease) and asthma.
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公开(公告)号：US06982256B2
公开(公告)日：2006-01-03
申请号：US10237918
申请日：2002-09-09
申请人： Christine Votteler , Bernd Kruss
发明人： Christine Votteler , Bernd Kruss
IPC分类号： A61K31/724
摘要： The invention relates to new formulations for improving the local tolerance of intravenously administered 4-(4-(2-pyrrolylcarbonyl)-1-piperazinyl)-3-trifluoromethyl-benzoylguanidine or one of the pharmacologically acceptable acid addition salts thereof.
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![Process for preparing 6-aryl-4H-S-triazolo[3,4-c]-thieno[2,3-e]-1,4-diazepines](/abs-image/US/2005/07/07/US20050148579A1/abs.jpg.150x150.jpg)
10.发明申请Process for preparing 6-aryl-4H-S-triazolo[3,4-c]-thieno[2,3-e]-1,4-diazepines 审中-公开6-芳基-4H-S-三唑并[3,4-c]噻吩并[2,3-e] -1,4-二氮杂的制备方法公开(公告)号：US20050148579A1
公开(公告)日：2005-07-07
申请号：US11074198
申请日：2005-03-07
申请人： Werner Belzer , Ralf Lock
发明人： Werner Belzer , Ralf Lock
IPC分类号： C07D495/04 , C07D495/14 , A61K31/551 , C07D498/14
CPC分类号： C07D495/04 , C07D495/14
摘要： An improved process for preparing 6-aryl-4H-s-triazolo[3,4-c]-thieno[2,3-e]-1,4-diazepines of formula I, wherein: R1 is a hydrogen or halogen atom or a C1-C6 alkyl group, R2 is a hydrogen or halogen atom or a C1-C6 alkyl, C1-C6 hydroxyalkyl, C3-C6 cycloalkyl group or a 5- or 6-membered oxygen-, sulphur- or nitrogen-containing heterocyclic group which may optionally be substituted at the nitrogen atom by a C1-C3 alkyl group, and R3 is a hydrogen or halogen atom,
摘要翻译： 用于制备式I的6-芳基-4H-三唑并[3,4-c]噻吩并[2,3-e] -1,4-二氮杂的改进方法，其中：R 1 >是氢或卤素原子或C 1 -C 6烷基，R 2是氢或卤素原子或C 1 -C 6烷基， C 1 -C 6烷基，C 1 -C 6羟烷基，C 3 -C 6烷基，C 1 -C 6烷基，C 1 -C 6 - C 6环烷基或可以任选地在氮原子上被C 1〜N取代的5-或6-元的含氧，含硫或含氮杂环基团， -C 3烷基，R 3是氢或卤素原子，
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