发明授权
US06974865B2 C3′ -methylene hydrogen phosphonate oligomers and related compounds
失效
C3'-亚甲基膦酸低聚物和相关化合物
- 专利标题： C3′ -methylene hydrogen phosphonate oligomers and related compounds
- 专利标题（中）： C3'-亚甲基膦酸低聚物和相关化合物
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申请号： US10322242申请日： 2002-12-18
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公开(公告)号： US06974865B2公开(公告)日： 2005-12-13
- 发明人: Phillip Dan Cook , Muthiah Manoharan , Martin Maier , Haoyun An
- 申请人： Phillip Dan Cook , Muthiah Manoharan , Martin Maier , Haoyun An
- 申请人地址： US CA Carlsbad
- 专利权人： ISIS Pharmaceuticals, Inc.
- 当前专利权人： ISIS Pharmaceuticals, Inc.
- 当前专利权人地址： US CA Carlsbad
- 代理机构： Isis Patent Department
- 主分类号： A61K49/00
- IPC分类号： A61K49/00 ; C07H19/06 ; C07H19/10 ; C07H21/00 ; C07H21/02 ; C07H21/04
摘要：
The present invention is directed to nucleoside monomers wherein the 3′-O atom is replaced with a methylene group. The present invention also provides oligomers comprising a plurality of such monomers which are linked by methylene phosphonate linkages. Further, methods of preparing monomers and oligomers according to the present invention are provided.
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