发明授权
- 专利标题： Quinazoline derivatives as kinase inhibitors
- 专利标题（中）： 喹唑啉衍生物作为激酶抑制剂
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申请号： US10344736申请日： 2001-08-17
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公开(公告)号： US06982266B2公开(公告)日： 2006-01-03
- 发明人: Anjali Pandey , Robert M. Scarborough , Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shinichi Ide , Eiji Tsukuda , Junko Sasaki , Shoji Oda
- 申请人： Anjali Pandey , Robert M. Scarborough , Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shinichi Ide , Eiji Tsukuda , Junko Sasaki , Shoji Oda
- 申请人地址： US MA Cambridge JP Tokyo
- 专利权人： Millennium Pharmaceuticals, Inc.,Kyowa Hakko Kogyo Co., Ltd.
- 当前专利权人： Millennium Pharmaceuticals, Inc.,Kyowa Hakko Kogyo Co., Ltd.
- 当前专利权人地址： US MA Cambridge JP Tokyo
- 代理机构： Townsend and Townsend and Crew LLP
- 国际申请： PCT/US01/41752 WO 20010817
- 国际公布： WO02/16351 WO 20020228
- 主分类号： A01K31/675
- IPC分类号： A01K31/675 ; A01K31/517 ; C07D43/02 ; C07D239/72
摘要：
The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.
公开/授权文献
- US20050101609A1 Quinazoline derivatives as kinase inhibitors 公开/授权日：2005-05-12
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