发明授权
US06995172B2 Lactam-containing compounds and derivatives thereof as factor Xa inhibitors
有权
含有内酰胺的化合物及其衍生物作为因子Xa抑制剂
- 专利标题： Lactam-containing compounds and derivatives thereof as factor Xa inhibitors
- 专利标题（中）： 含有内酰胺的化合物及其衍生物作为因子Xa抑制剂
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申请号： US10970807申请日： 2004-10-21
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公开(公告)号： US06995172B2公开(公告)日： 2006-02-07
- 发明人: Donald J. P. Pinto , Mimi L. Quan , Michael J. Orwat , Yun-Long Li , Wei Han , Jennifer X. Qiao , Patrick Y. S. Lam , Stephanie L. Koch
- 申请人： Donald J. P. Pinto , Mimi L. Quan , Michael J. Orwat , Yun-Long Li , Wei Han , Jennifer X. Qiao , Patrick Y. S. Lam , Stephanie L. Koch
- 申请人地址： US NJ Princeton
- 专利权人： Bristol-Myers Squibb Pharma Company
- 当前专利权人： Bristol-Myers Squibb Pharma Company
- 当前专利权人地址： US NJ Princeton
- 代理商 Jing Q. Sun; David H. Vance
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; A61K31/4162 ; A61P7/02
摘要：
The present application describes lactam-containing compounds and derivatives thereof of Formula I:P4-P-M-M4 Ior pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5–7 membered carbocycle or heterocycle and ring M is a 5–7 membered carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
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