发明授权
- 专利标题： Amide compounds and medicinal use thereof
- 专利标题（中）： 酰胺化合物及其药用
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申请号： US09913260申请日： 2000-02-10
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公开(公告)号： US07015218B1公开(公告)日： 2006-03-21
- 发明人: Hiroyuki Ushio , Seigo Ishibuchi , Youichiro Naito , Naoki Sugiyama , Takafumi Kawaguchi , Kenji Chiba , Makio Ohtsuki , Yoichi Naka
- 申请人： Hiroyuki Ushio , Seigo Ishibuchi , Youichiro Naito , Naoki Sugiyama , Takafumi Kawaguchi , Kenji Chiba , Makio Ohtsuki , Yoichi Naka
- 申请人地址： JP Osaka
- 专利权人： Mitsubishi Pharma Corporation
- 当前专利权人： Mitsubishi Pharma Corporation
- 当前专利权人地址： JP Osaka
- 代理机构： Wenderoth, Lind & Ponack, L.L.P.
- 优先权： JP11-033367 19990210; JP11-198473 19990713
- 国际申请： PCT/JP00/00767 WO 20000210
- 国际公布： WO00/47558 WO 20000817
- 主分类号： A61K31/541
- IPC分类号： A61K31/541 ; A61K31/5375 ; A61K31/496 ; A61K31/454 ; A61K31/4545
摘要：
The present invention relates to a compound of the formula wherein R1 is substituted aryl, heteroaryl and the like, R2 and R3 are hydrogen, alkyl, halogen, hydroxyl group and the like, Q is N, CH and the like, W is hydrogen, alkyl, hydroxycarbonylalkyl and the like, X is halogen, cyano, nitro, amino and the like, X′ is hydrogen, halogen, cyano, nitro, and Y is alkyl, hydroxyl group, alkoxy, mercapto and the like and a salt thereof, and a medicine containing the said compound. The compound of the present invention shows a superior inhibitory effect on activated lymphocytes proliferation and is useful as an agent for the prophylaxis or treatment of various autoimmune diseases.
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