Invention Grant
US07115373B2 Method of testing for atopic dermatitis by measuring expression of the NOR-1 gene
失效
通过测量NOR-1基因表达测定特应性皮炎的方法
- Patent Title: Method of testing for atopic dermatitis by measuring expression of the NOR-1 gene
- Patent Title (中): 通过测量NOR-1基因表达测定特应性皮炎的方法
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Application No.: US10608863Application Date: 2003-06-27
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Publication No.: US07115373B2Publication Date: 2006-10-03
- Inventor: Ryoichi Hashida , Shinji Kagaya , Yoshihiro Yayoi , Yuji Sugita , Hirohisa Saito
- Applicant: Ryoichi Hashida , Shinji Kagaya , Yoshihiro Yayoi , Yuji Sugita , Hirohisa Saito
- Applicant Address: JP Ibaraki JP Tokyo
- Assignee: Genox Research, Inc.,Japan as Represented by General Director of Agency of National Center For Child Health & Development
- Current Assignee: Genox Research, Inc.,Japan as Represented by General Director of Agency of National Center For Child Health & Development
- Current Assignee Address: JP Ibaraki JP Tokyo
- Agency: Hamilton, Brook, Smith & Reynolds, P.C.
- Priority: JP2002-188490 20020627
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12N5/08 ; C07H21/04
Abstract:
Genes whose expression differ between that in eosinophils collected from atopic dermatitis patients of the exabartation stage and those of the remission stage were searched via a differential display method. As a result, NOR-1 (MINOR) gene was successfully identified whose expression significantly increased in eosinophils of patients in the remission stage, a stage associated with a decrease of eosinophils. The present inventors discovered that the gene can be successfully employed in testing for allergic diseases and screening for candidate compounds for therapeutic agents.
Public/Granted literature
- US20040214192A1 Methods of testing for allergic diseases and therapeutic agents for treating same Public/Granted day:2004-10-28
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