公开(公告)号：US07115373B2

公开(公告)日：2006-10-03

申请号：US10608863

申请日：2003-06-27

申请人： Ryoichi Hashida ,  Shinji Kagaya ,  Yoshihiro Yayoi ,  Yuji Sugita ,  Hirohisa Saito

发明人： Ryoichi Hashida ,  Shinji Kagaya ,  Yoshihiro Yayoi ,  Yuji Sugita ,  Hirohisa Saito

IPC分类号： C12Q1/68 ,  C12N5/08 ,  C07H21/04

CPC分类号： C12Q1/6883 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/0306 ,  C07K14/705 ,  C12N15/8509 ,  C12Q1/6897 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N2800/202 ,  G01N2800/24 ,  C12Q2545/114 ,  C12Q2531/113

摘要： Genes whose expression differ between that in eosinophils collected from atopic dermatitis patients of the exabartation stage and those of the remission stage were searched via a differential display method. As a result, NOR-1 (MINOR) gene was successfully identified whose expression significantly increased in eosinophils of patients in the remission stage, a stage associated with a decrease of eosinophils. The present inventors discovered that the gene can be successfully employed in testing for allergic diseases and screening for candidate compounds for therapeutic agents.

摘要翻译： 通过差异显示法搜索表达不同于从分泌阶段的特应性皮炎患者和缓解期的嗜酸性粒细胞中表达不同的基因。 结果，成功鉴定了NOR-1（MINOR）基因，其在缓解期患者的嗜酸性粒细胞中的表达显着增加，这与嗜酸性粒细胞减少有关。 本发明人发现，该基因可以成功地用于过敏性疾病的检测和用于治疗剂的候选化合物的筛选。

公开(公告)号：US07172867B2

公开(公告)日：2007-02-06

申请号：US10611310

申请日：2003-07-01

申请人： Ryoichi Hashida ,  Shinji Kagaya ,  Yuji Sugita ,  Hirohisa Saito

发明人： Ryoichi Hashida ,  Shinji Kagaya ,  Yuji Sugita ,  Hirohisa Saito

IPC分类号： C12Q1/68 ,  C12P19/34

CPC分类号： C07K14/70567 ,  A01K2217/075 ,  A61K31/5575 ,  A61K38/00 ,  G01N2500/10

摘要： Differential expression of genes whose expression is different in the activated eosinophils of atopic dermatitis patients was measured by comparative analysis using a gene chip. As a result, the TR3 and TINUR genes, whose expression is significantly elevated in activated eosinophils, were successfully identified. The present inventors discovered that these genes can be used to test for allergic disease and to screen candidate compounds for therapeutic agents for allergic disease.

摘要翻译： 通过使用基因芯片的比较分析来测定特应性皮炎患者的活化嗜酸性粒细胞中表达不同的基因的差异表达。 结果，TR3和TINUR基因在活化嗜酸性粒细胞中的表达显着升高。 本发明人发现，这些基因可用于测试过敏性疾病并筛选用于过敏性疾病的治疗剂的候选化合物。

公开(公告)号：US09404082B2

公开(公告)日：2016-08-02

申请号：US13990991

申请日：2011-12-02

申请人： Tatsutoshi Nakahata ,  Kohichiro Tsuji ,  Feng Ma ,  Hirohisa Saito ,  Kenji Matsumoto

发明人： Tatsutoshi Nakahata ,  Kohichiro Tsuji ,  Feng Ma ,  Hirohisa Saito ,  Kenji Matsumoto

IPC分类号： C12N5/00 ,  C12N5/08 ,  C12Q1/02 ,  C12N5/0787 ,  C12N5/074 ,  G01N33/50

CPC分类号： C12N5/0642 ,  C12N5/0696 ,  C12N2501/125 ,  C12N2501/145 ,  C12N2501/165 ,  C12N2501/20 ,  C12N2501/22 ,  C12N2501/2303 ,  C12N2501/2305 ,  C12N2501/2306 ,  C12N2501/26 ,  C12N2502/02 ,  C12N2506/02 ,  C12N2506/45 ,  G01N33/5029 ,  G01N33/5047 ,  G01N33/505 ,  G01N2500/04 ,  G01N2500/10

摘要： The present invention relates to a method for producing human eosinophils from human pluripotent stem cells. More specifically, the present invention provides a method for producing human eosinophils from human pluripotent stem cells, which method comprises the steps of: (1) co-culturing, in the presence of VEGF, human pluripotent stem cells with cells separated from the AGM region of a mammalian fetus; (2) performing suspension culture using a medium comprising IL-3, IL-6, Flt3 ligand, SCF, TPO and serum; (3) performing suspension culture using a medium comprising IL-3, SCF, GM-CSF and serum; and, optionally, (4) performing suspension culture using a medium comprising IL-3, IL-5 and serum.

摘要翻译： 本发明涉及从人多能干细胞生产人嗜酸性粒细胞的方法。 更具体地说，本发明提供从人多能干细胞生产人嗜酸性粒细胞的方法，该方法包括以下步骤：（1）在VEGF的存在下，将人多能干细胞与从AGM区域分离的细胞共培养 的哺乳动物胎儿; （2）使用包含IL-3，IL-6，Flt3配体，SCF，TPO和血清的培养基进行悬浮培养; （3）使用包含IL-3，SCF，GM-CSF和血清的培养基进行悬浮培养; 和（4）使用包含IL-3，IL-5和血清的培养基进行悬浮培养。

公开(公告)号：US07904811B2

公开(公告)日：2011-03-08

申请号：US11220851

申请日：2005-09-08

申请人： Hirohisa Saito

发明人： Hirohisa Saito

IPC分类号： G06N3/00

CPC分类号： H04N1/00204 ,  H04N2201/0015 ,  H04N2201/0068 ,  H04N2201/0094 ,  H04N2201/33378

摘要： A storage device is disclosed. The storage device includes a text/image information memory unit, a unit that converts the data format of text/image information, a unit that communicates with a user terminal having a display, and a delivery unit configured to, in response to a request for the property of a file stored in the memory unit from the user terminal through the communication unit, show the property of the corresponding file stored in the memory unit on the display of the user terminal. When the user terminal requests a download of the file by selecting a file format applicable to binary image data, the conversion unit converts text/image information contained in the file into binary image data if the data format of the text/image information is not binary image data but is multilevel image data (color image). Then, the delivery unit sends the binary image data in the selected file format to the user terminal.

摘要翻译： 公开了一种存储装置。 存储装置包括文本/图像信息存储单元，转换文本/图像信息的数据格式的单元，与具有显示的用户终端进行通信的单元，以及传送单元，其被配置为响应于请求 通过通信单元从用户终端存储在存储器单元中的文件的属性显示存储在存储器单元中的用户终端的显示器上的对应文件的属性。 当用户终端通过选择适用于二进制图像数据的文件格式来请求下载文件时，如果文本/图像信息的数据格式不是二进制的，则转换单元将包含在文件中的文本/图像信息转换为二进制图像数据 图像数据，但是是多级图像数据（彩色图像）。 然后，发送单元将所选择的文件格式的二进制图像数据发送到用户终端。

公开(公告)号：US5336081A

公开(公告)日：1994-08-09

申请号：US982694

申请日：1992-11-24

申请人： Hirohisa Saito ,  Jeremy P. Hoblyn ,  Etsuo Abe

发明人： Hirohisa Saito ,  Jeremy P. Hoblyn ,  Etsuo Abe

IPC分类号： F23J7/00 ,  F23J15/00

CPC分类号： F23J7/00 ,  F23J15/003

摘要： In a device for removing nitrogen oxides from exhaust gas of a combustion device by spraying a treatment agent capable of chemically reducing nitrogen oxides contained in the exhaust gas from an injector in a combustion chamber or an exhaust passage of the combustion device, the effectiveness of the treatment agent is optimized by detecting a combustion condition of the combustion device, and supplying water and at least one treatment agent in a selective and alternating manner according the detected combustion condition.

摘要翻译： 在通过喷射能够化学还原包含在废气中的氮氧化物的处理剂从燃烧装置的燃烧室或排气通道中的喷射器中除去燃烧装置的废气中的氮氧化物的装置中， 通过检测燃烧装置的燃烧状态，并根据检测到的燃烧条件以选择性和交替的方式供给水和至少一种处理剂来优化处理剂。

公开(公告)号：US20100172390A1

公开(公告)日：2010-07-08

申请号：US12376911

申请日：2007-05-21

申请人： Hideki Matsubara ,  Hirohisa Saito ,  Fumitake Nakanishi ,  Shinji Matsukawa

发明人： Hideki Matsubara ,  Hirohisa Saito ,  Fumitake Nakanishi ,  Shinji Matsukawa

IPC分类号： H01S5/343 ,  H01L33/00 ,  H01S5/42

CPC分类号： H01S5/18369 ,  B82Y20/00 ,  H01S5/0206 ,  H01S5/0215 ,  H01S5/105 ,  H01S5/18308 ,  H01S5/18341 ,  H01S5/3202 ,  H01S5/34333 ,  H01S5/423 ,  H01S2301/173

摘要： A fabrication method of a surface-emitting laser element includes a step of preparing a conductive GaN multiple-region substrate including a high dislocation density high conductance region, a low dislocation density high conductance region and a low dislocation density low conductance region, as a conductive GaN substrate; a semiconductor layer stack formation step of forming a plurality of group III-V compound semiconductor layer stack including an emission layer on the substrate; and an electrode formation step of forming a semiconductor side electrode and a substrate side electrode. The semiconductor layer and electrodes are formed such that an emission region into which carriers flow in the emission layer is located above and within the span of the low dislocation density high conductance region. Thus, a surface-emitting laser element having uniform light emission at the emission region can be obtained with favorable yield.

摘要翻译： 表面发射激光元件的制造方法包括制备包括高位错密度高电导区，低位错密度高电导区和低位错密度低电导区的导电GaN多区衬底作为导电 GaN衬底; 在衬底上形成包括发射层的多个III-V族化合物半导体层堆叠的半导体层堆叠形成步骤; 以及形成半导体侧电极和基板侧电极的电极形成工序。 形成半导体层和电极，使得载流子在发射层中流动的发射区域位于低位错密度高电导区域的跨度之内和之内。 因此，可以以良好的产率获得在发射区域具有均匀发光的表面发射激光元件。

公开(公告)号：US20060055962A1

公开(公告)日：2006-03-16

申请号：US11220851

申请日：2005-09-08

申请人： Hirohisa Saito

发明人： Hirohisa Saito

IPC分类号： G06F3/12

CPC分类号： H04N1/00204 ,  H04N2201/0015 ,  H04N2201/0068 ,  H04N2201/0094 ,  H04N2201/33378

摘要： A storage device is disclosed. The storage device includes a text/image information memory unit, a unit that converts the data format of text/image information, a unit that communicates with a user terminal having a display, and a delivery unit configured to, in response to a request for the property of a file stored in the memory unit from the user terminal through the communication unit, show the property of the corresponding file stored in the memory unit on the display of the user terminal. When the user terminal requests a download of the file by selecting a file format applicable to binary image data, the conversion unit converts text/image information contained in the file into binary image data if the data format of the text/image information is not binary image data but is multilevel image data (color image). Then, the delivery unit sends the binary image data in the selected file format to the user terminal.

摘要翻译： 公开了一种存储装置。 存储装置包括文本/图像信息存储单元，转换文本/图像信息的数据格式的单元，与具有显示的用户终端进行通信的单元，以及传送单元，其被配置为响应于请求 通过通信单元从用户终端存储在存储器单元中的文件的属性显示存储在存储器单元中的用户终端的显示器上的对应文件的属性。 当用户终端通过选择适用于二进制图像数据的文件格式来请求下载文件时，如果文本/图像信息的数据格式不是二进制的，则转换单元将包含在文件中的文本/图像信息转换为二进制图像数据 图像数据，但是是多级图像数据（彩色图像）。 然后，发送单元将所选择的文件格式的二进制图像数据发送到用户终端。

公开(公告)号：US20130163253A1

公开(公告)日：2013-06-27

申请号：US13822159

申请日：2011-09-27

申请人： Hirohisa Saito ,  Hideki Matsubara ,  Yoshihiro Akahane ,  Satoshi Yamasaki ,  Makoto Nakabayashi

发明人： Hirohisa Saito ,  Hideki Matsubara ,  Yoshihiro Akahane ,  Satoshi Yamasaki ,  Makoto Nakabayashi

IPC分类号： H05K1/02 ,  F21V7/16

CPC分类号： C08J7/06 ,  C08J7/045 ,  C08J2327/18 ,  H01L33/60 ,  H05K1/0274 ,  H05K1/189 ,  H05K3/285 ,  H05K2201/10106 ,  H05K2201/2054 ,  H05K2203/095

摘要： Provided is a flexible printed circuit board having excellent flexibility and a diffusely reflective white surface (white surface) which does not tend to undergo color change even when irradiated with light such as short-wavelength light, i.e., has high light deterioration resistance, and does not tend to undergo color change even when placed in a high-temperature environment, i.e., has excellent thermal deterioration resistance. The white reflective flexible printed circuit board includes a flexible printed circuit board and a surface constituted by a white reflective material layer. The white reflective material layer is composed of a resin composition containing a fluororesin and an inorganic white pigment. Lighting equipment includes the white reflective flexible printed circuit board and an LED mounted on the surface side constituted by the white reflective material layer of the white reflective flexible printed circuit board.

摘要翻译： 本发明提供柔性印刷电路板，具有优异的柔性和漫反射白色表面（白色表面），即使用诸如短波长光的光（即具有高的耐光劣化性）也不会发生颜色变化，并且 即使放置在高温环境下也不会发生颜色变化，即具有优异的耐热劣化性。 白色反光柔性印刷电路板包括柔性印刷电路板和由白色反射材料层构成的表面。 白色反射材料层由含有氟树脂和无机白色颜料的树脂组合物构成。 照明设备包括白色反光柔性印刷电路板和安装在由白色反光柔性印刷电路板的白色反射材料层构成的表面侧上的LED。

公开(公告)号：US20130083513A1

公开(公告)日：2013-04-04

申请号：US13704597

申请日：2011-06-06

申请人： Hirohisa Saito ,  Hideki Matsubara ,  Yoshihiro Akahane

发明人： Hirohisa Saito ,  Hideki Matsubara ,  Yoshihiro Akahane

IPC分类号： F21S2/00 ,  G02F1/133 ,  F21V21/00

CPC分类号： F21S2/00 ,  F21V21/00 ,  G02F1/133 ,  G02F1/133615 ,  G02F2001/133601 ,  G02F2001/133628 ,  H01L33/64

摘要： A light source unit (100) switches one or more of light source groups (P, Q, R), each comprising one or more of light sources (110), ON and OFF for each light source group or each light source. The light source unit (100) includes: a flexible printed wiring board (120); one or more of light source groups (P, Q, R) mounted on a first surface of the flexible printed wiring board (120); and a metal support plate (130) attached to a second surface on the opposite side to the first surface of the flexible printed wiring board (120) via an adhesive layer (140). The heat conductivity of the adhesive layer (140) in the vertical direction is set so as to be less than the heat conductivity in a base material layer (121) of the flexible printed wiring board (120) in the vertical direction.

摘要翻译： 光源单元（100）为每个光源组或每个光源切换一个或多个光源组（P，Q，R），每个光源组包括一个或多个光源（110），ON和OFF。 光源单元（100）包括：柔性印刷布线板（120）; 安装在柔性印刷电路板（120）的第一表面上的一个或多个光源组（P，Q，R）; 以及金属支撑板（130），其经由粘合剂层（140）附接到与所述柔性印刷线路板（120）的所述第一表面相反的一侧的第二表面。 粘合剂层（140）在垂直方向上的导热率被设定为小于柔性印刷电路板（120）的基材层（121）在垂直方向上的导热率。

公开(公告)号：US08274088B2

公开(公告)日：2012-09-25

申请号：US12376911

申请日：2007-05-21

申请人： Hideki Matsubara ,  Hirohisa Saito ,  Fumitake Nakanishi ,  Shinji Matsukawa

发明人： Hideki Matsubara ,  Hirohisa Saito ,  Fumitake Nakanishi ,  Shinji Matsukawa

IPC分类号： H01L31/12 ,  H01L33/00

CPC分类号： H01S5/18369 ,  B82Y20/00 ,  H01S5/0206 ,  H01S5/0215 ,  H01S5/105 ,  H01S5/18308 ,  H01S5/18341 ,  H01S5/3202 ,  H01S5/34333 ,  H01S5/423 ,  H01S2301/173

摘要： A fabrication method of a surface-emitting laser element includes a step of preparing a conductive GaN multiple-region substrate including a high dislocation density high conductance region, a low dislocation density high conductance region and a low dislocation density low conductance region, as a conductive GaN substrate; a semiconductor layer stack formation step of forming a group III-V compound semiconductor layer stack including an emission layer on the substrate; and an electrode formation step of forming a semiconductor layer side electrode and a substrate side electrode. The semiconductor layer and electrodes are formed such that an emission region into which carriers flow in the emission layer is located above and within the span of the low dislocation density high conductance region. Thus, a surface-emitting laser element having uniform light emission at the emission region can be obtained with favorable yield.

摘要翻译： 表面发射激光元件的制造方法包括制备包括高位错密度高电导区，低位错密度高电导区和低位错密度低电导区的导电GaN多区衬底作为导电 GaN衬底; 在衬底上形成包括发射层的III-V族化合物半导体层堆叠的半导体层堆叠形成步骤; 以及形成半导体层侧电极和基板侧电极的电极形成工序。 形成半导体层和电极，使得载流子在发射层中流动的发射区域位于低位错密度高电导区域的跨度之内和之内。 因此，可以以良好的产率获得在发射区域具有均匀发光的表面发射激光元件。