公开(公告)号：US07115373B2

公开(公告)日：2006-10-03

申请号：US10608863

申请日：2003-06-27

申请人： Ryoichi Hashida ,  Shinji Kagaya ,  Yoshihiro Yayoi ,  Yuji Sugita ,  Hirohisa Saito

发明人： Ryoichi Hashida ,  Shinji Kagaya ,  Yoshihiro Yayoi ,  Yuji Sugita ,  Hirohisa Saito

IPC分类号： C12Q1/68 ,  C12N5/08 ,  C07H21/04

CPC分类号： C12Q1/6883 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/0306 ,  C07K14/705 ,  C12N15/8509 ,  C12Q1/6897 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N2800/202 ,  G01N2800/24 ,  C12Q2545/114 ,  C12Q2531/113

摘要： Genes whose expression differ between that in eosinophils collected from atopic dermatitis patients of the exabartation stage and those of the remission stage were searched via a differential display method. As a result, NOR-1 (MINOR) gene was successfully identified whose expression significantly increased in eosinophils of patients in the remission stage, a stage associated with a decrease of eosinophils. The present inventors discovered that the gene can be successfully employed in testing for allergic diseases and screening for candidate compounds for therapeutic agents.

摘要翻译： 通过差异显示法搜索表达不同于从分泌阶段的特应性皮炎患者和缓解期的嗜酸性粒细胞中表达不同的基因。 结果，成功鉴定了NOR-1（MINOR）基因，其在缓解期患者的嗜酸性粒细胞中的表达显着增加，这与嗜酸性粒细胞减少有关。 本发明人发现，该基因可以成功地用于过敏性疾病的检测和用于治疗剂的候选化合物的筛选。

公开(公告)号：US07172867B2

公开(公告)日：2007-02-06

申请号：US10611310

申请日：2003-07-01

申请人： Ryoichi Hashida ,  Shinji Kagaya ,  Yuji Sugita ,  Hirohisa Saito

发明人： Ryoichi Hashida ,  Shinji Kagaya ,  Yuji Sugita ,  Hirohisa Saito

IPC分类号： C12Q1/68 ,  C12P19/34

CPC分类号： C07K14/70567 ,  A01K2217/075 ,  A61K31/5575 ,  A61K38/00 ,  G01N2500/10

摘要： Differential expression of genes whose expression is different in the activated eosinophils of atopic dermatitis patients was measured by comparative analysis using a gene chip. As a result, the TR3 and TINUR genes, whose expression is significantly elevated in activated eosinophils, were successfully identified. The present inventors discovered that these genes can be used to test for allergic disease and to screen candidate compounds for therapeutic agents for allergic disease.

摘要翻译： 通过使用基因芯片的比较分析来测定特应性皮炎患者的活化嗜酸性粒细胞中表达不同的基因的差异表达。 结果，TR3和TINUR基因在活化嗜酸性粒细胞中的表达显着升高。 本发明人发现，这些基因可用于测试过敏性疾病并筛选用于过敏性疾病的治疗剂的候选化合物。