发明授权
- 专利标题： Process for the production of L-amino acids by fermentation using coryneform bacteria
- 专利标题（中）： 使用棒状细菌通过发酵生产L-氨基酸的方法
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申请号： US11264026申请日： 2005-11-02
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公开(公告)号： US07144724B2公开(公告)日： 2006-12-05
- 发明人: Mike Farwick , Brigitte Bathe , Thomas Hermann , Achim Marx , Walter Pfefferle
- 申请人： Mike Farwick , Brigitte Bathe , Thomas Hermann , Achim Marx , Walter Pfefferle
- 申请人地址： DE Hanau
- 专利权人： Degussa AG
- 当前专利权人： Degussa AG
- 当前专利权人地址： DE Hanau
- 代理机构： Venable LLP
- 代理商 Ann S. Hobbs
- 优先权： DE10117816 20010410
- 主分类号： C12N1/12
- IPC分类号： C12N1/12 ; C12N15/00 ; C12N1/20 ; C12N15/74 ; C07H21/02
摘要：
A process for the production of an L-amino acid wherein coryneform bacteria (e.g. Coryneform glutamicum) in which expression of the mqo gene coding for malate quinone oxidoreductase is attenuated are fermented to produce a desired amino acid, and the amino acid is concentrated in the medium or cells and isolated. Optionally, further genes in the biosynthetic pathway of the desired amino acid are enhanced, and/or metabolic pathways that reduce formation of the amino acid are suppressed.
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