发明授权
- 专利标题： Thrombin inhibitors
- 专利标题（中）： 凝血酶抑制剂
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申请号： US10467439申请日： 2002-02-05
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公开(公告)号： US07144899B2公开(公告)日： 2006-12-05
- 发明人: Harold G. Selnick , Mary Beth Young , Philippe G. Nantermet , James C. Barrow , Peter D. Williams , Terry A. Lyle , Donnette D. Staas , Kenneth J. Stauffer , Philip E. Sanderson
- 申请人： Harold G. Selnick , Mary Beth Young , Philippe G. Nantermet , James C. Barrow , Peter D. Williams , Terry A. Lyle , Donnette D. Staas , Kenneth J. Stauffer , Philip E. Sanderson
- 申请人地址： US NJ Rahway
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： US NJ Rahway
- 代理商 Richard S. Parr; Valerie J. Camara
- 国际申请： PCT/US02/04658 WO 20020205
- 国际公布： WO02/064559 WO 20020822
- 主分类号： A61K31/4439
- IPC分类号： A61K31/4439 ; C07D401/12
摘要：
Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure Formula (I): wherein u is CH or N; Q is 1)—N(R25)CH(R30)— wherein the nitrogen atom is attached to R1, and R25 and R30 are independently selected from the group consisting of hydrogen, C3-6cycloalkyl, and C1-6alkyl, or 2) wherein the nitrogen atom is attached to R1, and m is 0, 1, or 2
公开/授权文献
- US20040073025A1 Thrombin inhibitors 公开/授权日：2004-04-15
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