Invention Grant
- Patent Title: Environment responsive gelling copolymer
- Patent Title (中): 环境响应胶凝共聚物
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Application No.: US10221084Application Date: 2001-03-15
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Publication No.: US07193007B2Publication Date: 2007-03-20
- Inventor: Yu-Ling Cheng , Hai-Hui Lin
- Applicant: Yu-Ling Cheng , Hai-Hui Lin
- Agency: Brown Rudnick Berlack Israels LLP
- Agent Thomas M. Saunders
- International Application: PCT/CA01/00325 WO 20010315
- International Announcement: WO01/68768 WO 20010920
- Main IPC: C08F290/04
- IPC: C08F290/04 ; C08L53/00

Abstract:
The invention relates to a gelable copolymer composition comprising a copolymer in a solvent. The copolymer has the structure A(B)n, wherein the core (A) is soluble in the solvent, the arms (B) are convertible between soluble and insoluble in the solent depending on an environmental condition, and n>1. The composition forms a gel under environmental conditions in which B is insoluble, through formation of B aggregates. Block copolymers comprising polyethylene glycol (PEG) and poly(N-iso-propylacrylamide) (PNIPAAm) having a liquid form at ambient temperature under aqueous conditions and a gel form at body temperature are disclosed. Copolymer compositions according to the invention can be used to form in situ implants useful in slow-release formulations of biologically active molecules
Public/Granted literature
- US20050020719A1 Environment responsive gelling copolymer Public/Granted day:2005-01-27
Information query
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