公开(公告)号：US20070110784A1

公开(公告)日：2007-05-17

申请号：US10555455

申请日：2004-05-03

Applicant: Yu-Ling Cheng ,  Michael May ,  John Semple ,  Hai-Hui Lin

Inventor： Yu-Ling Cheng ,  Michael May ,  John Semple ,  Hai-Hui Lin

IPC: A61F2/02 ,  A61K8/73 ,  A61K8/81

CPC classification number: A61F2/0059

Abstract: The invention relates to the use of a thermal reversible gel, such as a copolymer composition, as a biological filler or implant. The gel has a semi-solid form at body temperature, but upon cooling to a temperature below a threshold level, the gel is liquefied and can be re-shaped, re-sized, manipulated or removed from the body. The gel may be used as a subcutaneous implant, a biological filler, joint or tissue spacer, for wrinkle filling or other cosmetic implants, as a soft-tissue replacement for reconstructive surgery, or as a barrier within the lumen of a biological structure, such as a blood vessel. The implant may be used to provide reversible birth control by providing, for example, a reversible barrier to the cervix or a reversible blockage of the lumen of the vas deferens.

Abstract translation: 本发明涉及热可逆凝胶如共聚物组合物作为生物填料或植入物的用途。 凝胶在体温下具有半固体形式，但是当冷却到低于阈值水平时，凝胶被液化，并且可以重新成形，重新调整尺寸，操作或从身体去除。 凝胶可以用作皮肤植入物，生物填充剂，关节或组织间隔物，用于皱纹填充或其它化妆品植入物，作为用于重建手术的软组织替代物，或作为生物结构内腔内的屏障，例如 作为血管。 植入物可用于通过提供例如子宫颈的可逆屏障或输精管腔的可逆阻塞来提供可逆的节育。

公开(公告)号：US07160931B2

公开(公告)日：2007-01-09

申请号：US10428520

申请日：2003-05-02

Applicant: Yu-Ling Cheng ,  Michael H. May ,  John L. Semple ,  Hai-Hui Lin

Inventor： Yu-Ling Cheng ,  Michael H. May ,  John L. Semple ,  Hai-Hui Lin

IPC: A61F2/00 ,  C08L51/00 ,  C08L53/00

CPC classification number: C08F283/06 ,  A61L24/06 ,  A61L27/16 ,  A61L27/50 ,  A61L27/52 ,  C08F293/00 ,  C08F297/00 ,  C08L51/003 ,  C08L51/08 ,  C08L53/00 ,  C08L53/005 ,  C08L33/26 ,  C08L2666/24 ,  C08L2666/02

Abstract: The invention relates to the use of a thermal reversible gel, such as a copolymer composition, as a biological filler or implant. The gel has a semi-solid form at body temperature, but upon cooling to a temperature below a threshold level, the gel is liquefied and can be re-shaped, re-sized, manipulated or removed from the body. The gel may be used as a subcutaneous implant, a biological filler, joint or tissue spacer, for wrinkle filling or other cosmetic implants, as a soft-tissue replacement for reconstructive surgery, or as a barrier within the lumen of a biological structure, such as a blood vessel. The implant may be used to provide reversible birth control by providing, for example, a reversible barrier to the cervix or a reversible blockage of the lumen of the vas deferens.

Abstract translation: 本发明涉及热可逆凝胶如共聚物组合物作为生物填料或植入物的用途。 凝胶在体温下具有半固体形式，但是当冷却到低于阈值水平时，凝胶被液化，并且可以重新成形，重新调整尺寸，操作或从身体去除。 凝胶可以用作皮肤植入物，生物填充剂，关节或组织间隔物，用于皱纹填充或其它化妆品植入物，作为用于重建手术的软组织替代物，或作为生物结构内腔内的屏障，例如 作为血管。 植入物可用于通过提供例如子宫颈的可逆屏障或输精管腔的可逆阻塞来提供可逆的节育。

公开(公告)号：US07193007B2

公开(公告)日：2007-03-20

申请号：US10221084

申请日：2001-03-15

Applicant: Yu-Ling Cheng ,  Hai-Hui Lin

Inventor： Yu-Ling Cheng ,  Hai-Hui Lin

IPC: C08F290/04 ,  C08L53/00

CPC classification number: C08L53/00 ,  A61L27/16 ,  A61L27/52 ,  C08F293/00 ,  C08F297/00 ,  Y10S524/916

Abstract: The invention relates to a gelable copolymer composition comprising a copolymer in a solvent. The copolymer has the structure A(B)n, wherein the core (A) is soluble in the solvent, the arms (B) are convertible between soluble and insoluble in the solent depending on an environmental condition, and n>1. The composition forms a gel under environmental conditions in which B is insoluble, through formation of B aggregates. Block copolymers comprising polyethylene glycol (PEG) and poly(N-iso-propylacrylamide) (PNIPAAm) having a liquid form at ambient temperature under aqueous conditions and a gel form at body temperature are disclosed. Copolymer compositions according to the invention can be used to form in situ implants useful in slow-release formulations of biologically active molecules

Abstract translation: 本发明涉及在溶剂中包含共聚物的可胶凝共聚物组合物。 共聚物具有结构A（B）n，其中核（A）可溶于溶剂，臂（B）可根据环境条件在可溶性和不溶性之间转化，并且n> 1。 组合物通过形成B聚集体在环境条件下形成凝胶，其中B不溶。 公开了包含聚乙二醇（PEG）和聚环氧乙烷（PNIPAAm）在环境温度和水温条件下具有液态的嵌段共聚物和体温下的凝胶形式。 根据本发明的共聚物组合物可用于形成用于生物活性分子的缓释制剂的原位植入物

公开(公告)号：US20050020719A1

公开(公告)日：2005-01-27

申请号：US10221084

申请日：2001-03-15

Applicant: Yu-Ling Cheng ,  Hai-Hui Lin

Inventor： Yu-Ling Cheng ,  Hai-Hui Lin

IPC: A61L27/16 ,  A61L27/52 ,  C08F293/00 ,  C08F297/00 ,  C08L53/00 ,  C08K3/00 ,  A61F2/00 ,  C08F20/54 ,  C08L1/00

CPC classification number: C08L53/00 ,  A61L27/16 ,  A61L27/52 ,  C08F293/00 ,  C08F297/00 ,  Y10S524/916

Abstract: The invention relates to a gelable copolymer composition comprising a copolymer in a solvent. The copolymer has the structure A(B)n, wherein the core (A) is soluble in the solvent, the arms (B) are convertible between soluble and insoluble in the solent depending on an environmental condition, and n>1. The composition forms a gel under environmental conditions in which B is insoluble, through formation of B aggregates. Block copolymers comprising polyethylene glycol (PEG) and poly(N-iso-propylacrylamide) (PNIPAAm) having a liquid form at ambient temperature under aqueous conditions and a gel form at body temperature are disclosed. Copolymer compositions according to the invention can be used to form in situ implants useful in slow-release formulations of biologically active molecules.

Abstract translation: 本发明涉及在溶剂中包含共聚物的可胶凝共聚物组合物。 共聚物具有结构A（B）n，其中核（A）可溶于溶剂，臂（B）可根据环境条件在可溶性和不溶性之间转化，并且n> 1。 组合物通过形成B聚集体在环境条件下形成凝胶，其中B不溶。 公开了包含聚乙二醇（PEG）和聚环氧乙烷（PNIPAAm）在环境温度和水温条件下具有液态的嵌段共聚物和体温下的凝胶形式。 根据本发明的共聚物组合物可用于形成用于生物活性分子的缓释制剂的原位植入物。

公开(公告)号：US20080287331A1

公开(公告)日：2008-11-20

申请号：US11859820

申请日：2007-09-24

Applicant: Hai-Hui Lin ,  Marc Hein ,  Xintong Lu

Inventor： Hai-Hui Lin ,  Marc Hein ,  Xintong Lu

IPC: C11D1/38

CPC classification number: C11D1/38 ,  C11D1/62 ,  C11D1/72 ,  C11D1/835 ,  C11D3/201 ,  C11D3/2013 ,  C11D3/2068 ,  C11D3/2072 ,  C11D3/2093 ,  C11D3/24 ,  C11D3/43 ,  C11D11/0041 ,  C11D17/0021

Abstract: A cleaning composition for cleaning printing components such as printing blankets and inking rollers is provided having a VOC content of less than about 10%. The composition includes a cationic surfactant containing no halides, a co-microemulsifying surfactant, and a solvent selected from a low-VOC solvent, a VOC-exempt solvent, or combinations thereof. The cleaning composition may be applied to the surface of a printing press component containing ink and then wiped away.

Abstract translation: 提供了具有小于约10％的VOC含量的清洁印刷部件如印刷毛毯和着墨辊的清洁组合物。 该组合物包括不含卤化物的阳离子表面活性剂，共微乳化表面活性剂和选自低VOC溶剂，VOC-免除溶剂或其组合的溶剂。 清洁组合物可以施加到包含油墨的印刷机部件的表面上，然后擦去。