发明授权
- 专利标题： Peptides and derivatives thereof showing cell attachment, spreading and detachment activity
- 专利标题（中）： 肽及其衍生物显示细胞附着，扩散和分离活性
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申请号： US11307490申请日： 2006-02-09
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公开(公告)号： US07250400B2公开(公告)日： 2007-07-31
- 发明人: In-San Kim , Jung-Eun Kim
- 申请人： In-San Kim , Jung-Eun Kim
- 申请人地址： KR Seoul
- 专利权人： Regen Biotech, Inc.
- 当前专利权人： Regen Biotech, Inc.
- 当前专利权人地址： KR Seoul
- 代理机构： JHK Law
- 代理商 Joseph Hyosuk Kim
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K38/04 ; C07K5/00 ; C07K7/00 ; C07K16/00 ; C07K17/00 ; C12N15/00 ; C12N5/00 ; C12N5/02 ; C12P21/06 ; C07K1/00
摘要：
The present invention relates to peptides and derivatives thereof showing cell attachment, spreading and detachment activity. Particularly, the present invention relates to the peptide NKDIL (SEQ ID NO:2) and EPDIM (SEQ ID NO:3) and derivatives thereof which promote the cell attachment activity through interaction with α3β1 integrin as a functional cell receptor and include aspartic acid and isoleucine essential for cell attachment and detachment activity. The peptides and derivatives thereof in the present invention can be used for developing a study of cell attachment activity mediated through various extracellular matrix protein containing βig-h3, wound healing, tissue regeneration and metastasis inhibition.