发明授权
- 专利标题： Recombinant histidine-tagged inosine monophosphate dehydrogenase polypeptides
- 专利标题（中）： 重组组氨酸标记的肌苷单磷酸脱氢酶多肽
-
申请号： US10769481申请日： 2004-01-30
-
公开(公告)号： US07276362B2公开(公告)日： 2007-10-02
- 发明人: Allan R. Dorn , Janice E. Rugaber
- 申请人： Allan R. Dorn , Janice E. Rugaber
- 申请人地址： US IN Indianapolis
- 专利权人： Roche Diagnostics Operations, Inc.
- 当前专利权人： Roche Diagnostics Operations, Inc.
- 当前专利权人地址： US IN Indianapolis
- 代理机构： Roche Diagnostics Operations, Inc.
- 代理商 Marilyn L. Amick
- 主分类号： C12N9/02
- IPC分类号： C12N9/02 ; C12N1/20 ; C12N15/00 ; C12N9/00 ; C07H21/04
摘要：
The invention relates to a modified IMPDH polypeptide wherein the IMPDH polypeptide has a histidine tag and where the subdomain of the IMPDH polypeptide is modified so that the rate stability of the histidine-tagged, modified IMPDH polypeptide is maintained relative to the wild-type IMPDH polypeptide. The invention also relates to a method, nucleic acid molecules, vectors, and host cells for producing such a histidine-tagged, modified IMPDH polypeptide, and to kits comprising the histidine-tagged, modified IMPDH polypeptide.
公开/授权文献
- US20050202520A1 Modified inosine monophosphate dehydrogenases 公开/授权日：2005-09-15
信息查询
