发明授权
- 专利标题: Device for magnetic immobilization of cells
- 专利标题(中): 细胞磁固定装置
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申请号: US10084063申请日: 2002-02-28
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公开(公告)号: US07285412B2公开(公告)日: 2007-10-23
- 发明人: Rocco Casagrande , Evelyn Wang , Gregory Kirk , Michael Nussbaum , Enoch Kim , Aaron Raphel
- 申请人: Rocco Casagrande , Evelyn Wang , Gregory Kirk , Michael Nussbaum , Enoch Kim , Aaron Raphel
- 申请人地址: US MA Brighton
- 专利权人: Surface Logix Inc.
- 当前专利权人: Surface Logix Inc.
- 当前专利权人地址: US MA Brighton
- 代理机构: Kenyon & Kenyon LLP
- 主分类号: C12M1/12
- IPC分类号: C12M1/12 ; C12M1/34 ; C12N11/02 ; C12N11/08
摘要:
The present invention relates to an apparatus and methods that immobilize one or more cells associated with magnetic material on a substrate on which are located one or more magnetic receptacle(s). Alternatively, in another aspect the present invention, the device arrays cells associated with magnetic material on a substrate having a pattern of magnetic receptacles disposed thereon. The size of the magnetic receptacle(s) determines the number of target cells that it is capable of immobilizing. The size of the magnetic receptacle is defined by the strength of a localized magnetic field gradient. The localized magnetic field gradient may be derived from 1) permanent magnets embedded in the substrate or alternatively, the localized magnetic field gradient may be derived from an 2) external magnet whose strength is focused by objects of highly-permeable-magnetic material which create localized magnetic field gradients. The invention apparatus comprises a removable cell delivery device and a substrate, which has one or more magnetic receptacles disposed thereon.
公开/授权文献
- US20030022370A1 Magnetic immobilization of cells 公开/授权日:2003-01-30
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