发明授权
US07285654B2 Stimulus-inducible protein kinase complex and methods of use therefor
失效
刺激诱导型蛋白激酶复合物及其使用方法
- 专利标题： Stimulus-inducible protein kinase complex and methods of use therefor
- 专利标题（中）： 刺激诱导型蛋白激酶复合物及其使用方法
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申请号： US10338462申请日： 2003-01-08
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公开(公告)号： US07285654B2公开(公告)日： 2007-10-23
- 发明人: Frank Mercurio , Hengyi Zhu , Miguel Barbosa , Jian Wu Li , Brion W. Murray
- 申请人： Frank Mercurio , Hengyi Zhu , Miguel Barbosa , Jian Wu Li , Brion W. Murray
- 申请人地址： US CA San Diego
- 专利权人： Signal Pharmaceuticals
- 当前专利权人： Signal Pharmaceuticals
- 当前专利权人地址： US CA San Diego
- 代理机构： Jones Day
- 主分类号： C02H21/04
- IPC分类号： C02H21/04 ; C12N9/12 ; C12N15/63 ; C12N1/20 ; C12N15/00
摘要：
Compositions and methods are provided for treating NF-κB-related conditions. In particular, the invention provides a stimulus-inducible IKK signalsome, and components and variants thereof. An IKK signalsome or component thereof may be used, for example, to identify antibodies and other modulating agents that inhibit or activate signal transduction via the NF-κB cascade. IKK signalsome, components thereof and/or modulating agents may also be used for the treatment of diseases associated with NF-κB activation.
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