发明授权
- 专利标题： Microorganisms and processes for enhanced production of pantothenate
- 专利标题（中）： 用于增加泛酸盐生产的微生物和方法
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申请号： US10614333申请日： 2003-07-03
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公开(公告)号： US07291489B2公开(公告)日： 2007-11-06
- 发明人: R. Rogers Yocum , Thomas A. Patterson , Janice G. Pero , Theron Hermann
- 申请人： R. Rogers Yocum , Thomas A. Patterson , Janice G. Pero , Theron Hermann
- 申请人地址： DE
- 专利权人： BASF Aktiengesellschaft
- 当前专利权人： BASF Aktiengesellschaft
- 当前专利权人地址： DE
- 代理机构： Lahive & Cockfield, LLP
- 主分类号： C12P13/04
- IPC分类号： C12P13/04 ; C12N9/00 ; C12N1/20 ; C12N15/00 ; C07H21/04
摘要：
The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate, by increasing enzymes or substrates that contribute directly or indirectly to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.
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