Invention Grant
- Patent Title: Mitotic kinesin inhibitors
- Patent Title (中): 有丝分裂驱动蛋白抑制剂
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Application No.: US10517576Application Date: 2003-06-12
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Publication No.: US07301028B2Publication Date: 2007-11-27
- Inventor: Kenneth L. Arrington , Mark E. Fraley
- Applicant: Kenneth L. Arrington , Mark E. Fraley
- Applicant Address: US NJ Rahway
- Assignee: Merck & Co., Inc.
- Current Assignee: Merck & Co., Inc.
- Current Assignee Address: US NJ Rahway
- Agent Nicole M. Beeler; David A. Muthard
- International Application: PCT/US03/18694 WO 20030612
- International Announcement: WO03/106417 WO 20031224
- Main IPC: C07D401/02
- IPC: C07D401/02 ; C07D293/10 ; C07D291/00 ; C07D265/00 ; C07D257/12 ; C07D251/00 ; C07D213/00 ; C07D221/02 ; C07D211/00 ; C07D421/00 ; C07D271/00 ; C07D277/04 ; C07D513/00 ; A01N43/00 ; A01N43/62 ; A01N43/66 ; A01N43/58 ; A01N43/40 ; A01N43/64 ; A61K31/54 ; A61K31/535 ; A61K31/40
Abstract:
The present invention relates to dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
Public/Granted literature
- US20060063942A1 Mitotic kinesin inhibitors Public/Granted day:2006-03-23
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