发明授权
- 专利标题： Polypeptide having an activity to support proliferation or survival of hematopoietic stem cell and hematopoietic progenitor cell, and DNA coding for the same
- 专利标题（中）： 具有支持造血干细胞和造血祖细胞的增殖或存活的活性的多肽和编码其的DNA
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申请号： US10478926申请日： 2002-06-11
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公开(公告)号： US07320880B2公开(公告)日： 2008-01-22
- 发明人: Mitsuo Nishikawa , Radoje T. Drmanac , Ivan Lobal , Y. Tom Tang , Juhi Lee , Birgit Stache-Crain
- 申请人： Mitsuo Nishikawa , Radoje T. Drmanac , Ivan Lobal , Y. Tom Tang , Juhi Lee , Birgit Stache-Crain
- 申请人地址： US CA San Carlos JP Tokyo
- 专利权人： Nuvelo, Inc.,Kirin Beer Kabushiki Kaisha
- 当前专利权人： Nuvelo, Inc.,Kirin Beer Kabushiki Kaisha
- 当前专利权人地址： US CA San Carlos JP Tokyo
- 代理机构： Robins & Pasternak LLP
- 国际申请： PCT/JP02/05807 WO 20020611
- 国际公布： WO02/100898 WO 20021219
- 主分类号： C07H21/04
- IPC分类号： C07H21/04 ; C07K14/475 ; C12N5/00 ; C12N1/00 ; C12P21/02
摘要：
A gene encoding a polypeptide having an activity to support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is isolated by comparing expressed genes between cells which support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells which do not support the proliferation or survival. Proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is supported by using stromal cells in which the isolated gene is expressed or a gene product of the isolated gene.
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