发明授权
US07332498B2 Modulation of KSP kinesin activity with heterocyclic-fused pyrimidinone derivatives
失效
用杂环稠合嘧啶酮衍生物调节KSP驱动蛋白活性
- 专利标题： Modulation of KSP kinesin activity with heterocyclic-fused pyrimidinone derivatives
- 专利标题（中）： 用杂环稠合嘧啶酮衍生物调节KSP驱动蛋白活性
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申请号： US11284806申请日： 2005-11-23
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公开(公告)号： US07332498B2公开(公告)日： 2008-02-19
- 发明人: Pu-Ping Lu , David J. Morgans, Jr. , Bing Yao , Dashyant Dhanak , Steven David Knight
- 申请人： Pu-Ping Lu , David J. Morgans, Jr. , Bing Yao , Dashyant Dhanak , Steven David Knight
- 申请人地址： US CA South San Francisco US PA Philadelphia
- 专利权人： Cytokinetics, Inc.,SmithKline Beecham Corporation
- 当前专利权人： Cytokinetics, Inc.,SmithKline Beecham Corporation
- 当前专利权人地址： US CA South San Francisco US PA Philadelphia
- 代理机构： Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- 主分类号： A61K31/519
- IPC分类号： A61K31/519 ; A61K31/5025 ; C07D471/04 ; C07D487/04 ; C07D498/04 ; C07D211/78 ; C07D211/82 ; C07D211/70 ; C07D211/90 ; C07D211/72 ; C07D211/84 ; C07D213/84 ; C07D213/72 ; C07D213/78 ; C07D213/46 ; C07D213/56
摘要：
A method of modulating KSP kinesin activity in vitro comprising contacting KSP kinesin with at least one chemical entity chosen from compounds represented by Formula I: and pharmaceutically acceptable salts thereof, where the variables are as defined further herein.
公开/授权文献
- US20060111374A1 Compounds, compositions, and methods 公开/授权日：2006-05-25
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