发明授权
- 专利标题： 3-aryl-isoxazole-4-carbonyl-benzofuran derivatives
- 专利标题（中）： 3-芳基 - 异恶唑-4-羰基 - 苯并呋喃衍生物
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申请号： US11590571申请日： 2006-10-31
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公开(公告)号： US07388025B2公开(公告)日： 2008-06-17
- 发明人: Bernd Buettelmann , Bo Han , Henner Knust , Matthias Nettekoven , Andrew Thomas
- 申请人： Bernd Buettelmann , Bo Han , Henner Knust , Matthias Nettekoven , Andrew Thomas
- 申请人地址： US NJ Nutley
- 专利权人： Hoffman-La Roche Inc.
- 当前专利权人： Hoffman-La Roche Inc.
- 当前专利权人地址： US NJ Nutley
- 代理商 George W. Johnston; Patricia S. Rocha-Tramaloni; Kimberly J. Prior
- 优先权： EP05110503 20051109
- 主分类号： A61K31/42
- IPC分类号： A61K31/42 ; C07D413/02
摘要：
The present invention is concerned with 3-aryl-isoxazole-4-carbonyl-benzofuran derivatives of formula I wherein R1, R2, and R3 are as defined in the specification and claims and with their pharmaceutically acceptable acid addition salts. These compounds have a high affinity and selectivity for GABA A α5 receptor binding sites and might be useful as cognitive enhancer or for the treatment of cognitive disorders like Alzheimer's disease.
公开/授权文献
- US20070105922A1 3-aryl-isoxazole-4-carbonyl-indole derivatives 公开/授权日：2007-05-10