发明授权
US07390633B2 Methods for preparing low molecular weight heparin with modified heparinase III
有权
用改良的肝素酶III制备低分子肝素的方法
- 专利标题： Methods for preparing low molecular weight heparin with modified heparinase III
- 专利标题（中）： 用改良的肝素酶III制备低分子肝素的方法
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申请号： US11406214申请日： 2006-04-18
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公开(公告)号： US07390633B2公开(公告)日： 2008-06-24
- 发明人: Dongfang Liu , Kevin Pojasek , Zachary Shriver , Kristine Holley , Yosuf El-Shabrawi , Ganesh Venkataraman , Ram Sasisekharan
- 申请人： Dongfang Liu , Kevin Pojasek , Zachary Shriver , Kristine Holley , Yosuf El-Shabrawi , Ganesh Venkataraman , Ram Sasisekharan
- 申请人地址： US MA Cambridge
- 专利权人： Massachusetts Institute of Technology
- 当前专利权人： Massachusetts Institute of Technology
- 当前专利权人地址： US MA Cambridge
- 代理机构： Wolf, Greenfield & Sacks, P.C.
- 主分类号： C12P1/00
- IPC分类号： C12P1/00 ; C12P21/00 ; C12N9/24 ; C12N1/20 ; C12N15/00
摘要：
The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of heparin-like glycosaminoglycans (HLGAGs), removing active heparan sulfate from a solution, inhibition of angiogenesis, etc. have been discovered according to the invention. The invention in other aspects relates to methods of treating cancer and inhibiting tumor cell growth and/or metastasis using heparinase III, or products produced by enzymatic cleavage by heparinase III of HLGAGs.
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