发明授权
- 专利标题: Primitive and proximal hepatic stem cells
- 专利标题(中): 原始和近端肝干细胞
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申请号: US10387547申请日: 2003-03-14
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公开(公告)号: US07413897B2公开(公告)日: 2008-08-19
- 发明人: Lola M. Reid , Nicholas Moss , Mark Furth , John W. Ludlow , Andrew T. Bruce
- 申请人: Lola M. Reid , Nicholas Moss , Mark Furth , John W. Ludlow , Andrew T. Bruce
- 申请人地址: US NC Chapel Hill US MD Bethesda
- 专利权人: University of North Carolina at Chapel Hill,Vesta Therapeutics, Inc.
- 当前专利权人: University of North Carolina at Chapel Hill,Vesta Therapeutics, Inc.
- 当前专利权人地址: US NC Chapel Hill US MD Bethesda
- 代理机构: Foley & Lardner LLP
- 代理商 Gilberto M. Villacorta; Sunit Talapatra
- 主分类号: C12N5/00
- IPC分类号: C12N5/00 ; A01N63/00
摘要:
Hepatic progenitors comprise two populations of human hepatic stem cells, primitive and proximal hepatic stem cells, and two populations of committed progenitors, one for biliary cells and one for hepatocytes. Human primitive hepatic stem cells are a very small fraction of the liver cell population and give rise to proximal hepatic stem cells constituting a much larger fraction of the liver. Human proximal hepatic stem cells give rise to biliary and hepatocyte committed progenitors. Primitive and proximal stem cells are the primary stem cells for the human liver. Human primitive hepatic stem cells may be isolated by immunoselection from human livers or culturing human liver cells under conditions which select for a human primitive hepatic stem cell. Proximal hepatic stem cells may be isolated by immunoselection, or by culturing human liver cells under conditions which include a developmental factor. Proximal hepatic stem cells may also be isolated by culturing colonies comprising a primitive hepatic stem cell under conditions which include a developmental factor. Resulting compositions may be used for treating liver disorders and for producing bioartificial organs.
公开/授权文献
- US20040018621A1 Primitive and proximal hepatic stem cells 公开/授权日:2004-01-29