发明授权
- 专利标题： Humanized anti-CCR2 antibodies and methods of use therefor
- 专利标题（中）： 人源化抗CCR2抗体及其使用方法
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申请号： US10766610申请日： 2004-01-27
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公开(公告)号： US07442775B2公开(公告)日： 2008-10-28
- 发明人: Gregory J. LaRosa , Christopher Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
- 申请人： Gregory J. LaRosa , Christopher Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
- 申请人地址： US MA Cambridge
- 专利权人： Millennium Pharmaceuticals, Inc.
- 当前专利权人： Millennium Pharmaceuticals, Inc.
- 当前专利权人地址： US MA Cambridge
- 代理机构： Lowrie, Lando & Anastasi, LLP
- 主分类号： C07H23/00
- IPC分类号： C07H23/00 ; A61K39/00 ; C12N15/00
摘要：
The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.
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