发明授权
- 专利标题: Methods for analyzing inter-cellular phenomena
- 专利标题(中): 分析细胞间现象的方法
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申请号: US11123610申请日: 2005-05-04
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公开(公告)号: US07450229B2公开(公告)日: 2008-11-11
- 发明人: William E. Ortyn , David A. Basiji , David H. Lynch
- 申请人: William E. Ortyn , David A. Basiji , David H. Lynch
- 申请人地址: US WA Seattle
- 专利权人: Amnis Corporation
- 当前专利权人: Amnis Corporation
- 当前专利权人地址: US WA Seattle
- 代理商 Ronald M. Anderson
- 主分类号: G01J3/28
- IPC分类号: G01J3/28 ; G01J3/51
摘要:
Aspects of the present invention encompass the collection of multispectral images from a population of objects, and the analysis of the collected images to measure at least one characteristic of the population, using photometric and/or morphometric features identifiable in the collection of images. In an exemplary application, the objects are biological cells. In a particularly preferred, but not limiting implementation, the plurality of images for each individual object are collected simultaneously. In an empirical study, the characteristic being measured involves the synapse between conjugated cells. The conjugated cells may represent a subpopulation of the overall population of objects that were imaged. In a particularly preferred, yet not limiting embodiment, the present invention enables the quantization of the redistribution of cellular molecules due to the conjugation of different biological cells. Significantly, such quantization is not feasible with standard microscopy and flow cytometry.
公开/授权文献
- US20060068371A1 Methods for analyzing inter-cellular phenomena 公开/授权日:2006-03-30