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    Fas antagonists and uses thereof
    3.
    发明授权
    Fas antagonists and uses thereof 失效
    Fas拮抗剂及其用途

    公开(公告)号：US5830469A

    公开(公告)日：1998-11-03

    申请号：US429499

    申请日：1995-04-26

    申请人： David H. Lynch ,  Mark R. Alderson

    发明人： David H. Lynch ,  Mark R. Alderson

    IPC分类号： A61K38/00 ,  A61P37/06 ,  C07K16/28 ,  A61K39/395 ,  A61K35/12 ,  C07K16/18 ,  C12N5/12

    CPC分类号： C07K16/2878 ,  A61K38/00 ,  C07K2317/74

    摘要： The present invention provides a panel of monoclonal antibodies and binding proteins which specifically bind to human Fas antigen. Some of the antibodies and binding proteins are capable of stimulating T cell proliferation, inhibiting binding of anti-Fas CH-11 monoclonal antibody to cells expressing Fas antigen, blocking anti-Fas CH-11 monoclonal antibody-mediated lysis of cells, and blocking Fas ligand-mediated lysis of cells. The invention also provides for therapeutic compositions comprising the monoclonal antibodies.

    摘要翻译： 本发明提供了一组特异性结合人Fas抗原的单克隆抗体和结合蛋白。 一些抗体和结合蛋白能够刺激T细胞增殖，抑制抗Fas CH-11单克隆抗体与表达Fas抗原的细胞的结合，阻断抗Fas CH-11单克隆抗体介导的细胞裂解，并阻断Fas 配体介导的细胞裂解。 本发明还提供包含单克隆抗体的治疗组合物。

    Human anti-Fas IgG1 monoclonal antibodies
    4.
    发明授权
    Human anti-Fas IgG1 monoclonal antibodies 失效
    人抗Fas IgG1单克隆抗体

    公开(公告)号：US5620889A

    公开(公告)日：1997-04-15

    申请号：US322805

    申请日：1994-10-13

    申请人： David H. Lynch ,  Mark R. Alderson

    发明人： David H. Lynch ,  Mark R. Alderson

    IPC分类号： C12N15/02 ,  A61K38/00 ,  A61K39/395 ,  A61P37/00 ,  C07K16/18 ,  C07K16/28 ,  C12N15/09 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  C12R1/91 ,  C12N5/12 ,  C07K16/22

    CPC分类号： C07K16/2878 ,  A61K38/00 ,  C07K2317/73

    摘要： The present invention provides a panel of monoclonal antibodies and binding proteins which specifically bind to human Fas antigen. Some of the antibodies and binding proteins are capable of stimulating T cell proliferation, inhibiting binding of anti-Fas CH-11 monoclonal antibody to cells expressing Fas antigen, blocking anti-Fas CH-11 monoclonal antibody-mediated lysis of cells, and blocking Fas ligand-mediated lysis of cells. The invention also provides for therapeutic compositions comprising the monoclonal antibodies.

    摘要翻译： 本发明提供了一组特异性结合人Fas抗原的单克隆抗体和结合蛋白。 一些抗体和结合蛋白能够刺激T细胞增殖，抑制抗Fas CH-11单克隆抗体与表达Fas抗原的细胞的结合，阻断抗Fas CH-11单克隆抗体介导的细胞裂解，并阻断Fas 配体介导的细胞裂解。 本发明还提供包含单克隆抗体的治疗组合物。

    Methods for analyzing inter-cellular phenomena
    5.
    发明授权
    Methods for analyzing inter-cellular phenomena 有权
    分析细胞间现象的方法

    公开(公告)号：US07450229B2

    公开(公告)日：2008-11-11

    申请号：US11123610

    申请日：2005-05-04

    申请人： William E. Ortyn ,  David A. Basiji ,  David H. Lynch

    发明人： William E. Ortyn ,  David A. Basiji ,  David H. Lynch

    IPC分类号： G01J3/28 ,  G01J3/51

    CPC分类号： G01N33/505 ,  G01J3/2889 ,  G01J3/36 ,  G01J3/4406 ,  G01N15/1429 ,  G01N15/147 ,  G01N15/1475 ,  G01N21/53 ,  G01N21/6428 ,  G01N21/6456 ,  G01N21/6458 ,  G01N33/5005 ,  G01N2015/1006 ,  G01N2015/1497 ,  G01N2021/6421 ,  G01N2021/6441 ,  G06K9/00127

    摘要： Aspects of the present invention encompass the collection of multispectral images from a population of objects, and the analysis of the collected images to measure at least one characteristic of the population, using photometric and/or morphometric features identifiable in the collection of images. In an exemplary application, the objects are biological cells. In a particularly preferred, but not limiting implementation, the plurality of images for each individual object are collected simultaneously. In an empirical study, the characteristic being measured involves the synapse between conjugated cells. The conjugated cells may represent a subpopulation of the overall population of objects that were imaged. In a particularly preferred, yet not limiting embodiment, the present invention enables the quantization of the redistribution of cellular molecules due to the conjugation of different biological cells. Significantly, such quantization is not feasible with standard microscopy and flow cytometry.

    摘要翻译： 本发明的方面包括从对象群体收集多光谱图像，以及使用在图像集合中可识别的光度和/或形态测量特征来分析收集的图像以测量群体的至少一个特征。 在示例性应用中，对象是生物细胞。 在特别优选但不是限制的实现中，用于每个单独对象的多个图像被同时收集。 在实证研究中，所测量的特征涉及共轭细胞之间的突触。 共轭细胞可以代表成像对象的总体群体的亚群。 在特别优选的但不是限制性的实施方案中，本发明使得由于不同生物细胞的共轭而能够量化细胞分子的再分布。 值得注意的是，这种量化在标准显微镜和流式细胞术中是不可行的。

    Fas antagonists
    8.
    发明授权
    Fas antagonists 失效
    Fas拮抗剂

    公开(公告)号：US6015559A

    公开(公告)日：2000-01-18

    申请号：US152733

    申请日：1998-09-14

    申请人： David H. Lynch ,  Mark R. Alderson

    发明人： David H. Lynch ,  Mark R. Alderson

    IPC分类号： A61K38/00 ,  A61P37/06 ,  C07K16/28 ,  A61K39/395 ,  C07K16/00 ,  C12N5/06

    CPC分类号： C07K16/2878 ,  A61K38/00 ,  C07K2317/74

    摘要： The present invention provides a panel of monoclonal antibodies and binding proteins which specifically bind to human Fas antigen. Some of the antibodies and binding proteins are capable of stimulating T cell proliferation, inhibiting binding of anti-Fas CH-11 monoclonal antibody to cells expressing Fas antigen, blocking anti-Fas CH-11 monoclonal antibody-mediated lysis of cells, and blocking Fas ligand-mediated lysis of cells. The invention also provides for therapeutic compositions comprising the monoclonal antibodies.

    摘要翻译： 本发明提供了一组特异性结合人Fas抗原的单克隆抗体和结合蛋白。 一些抗体和结合蛋白能够刺激T细胞增殖，抑制抗Fas CH-11单克隆抗体与表达Fas抗原的细胞的结合，阻断抗Fas CH-11单克隆抗体介导的细胞裂解，并阻断Fas 配体介导的细胞裂解。 本发明还提供包含单克隆抗体的治疗组合物。

    Adoptive immunotherapy with interleukin-7
    9.
    发明授权
    Adoptive immunotherapy with interleukin-7 失效
    采用INTERLEUKIN-7进行自主免疫治疗

    公开(公告)号：US5229115A

    公开(公告)日：1993-07-20

    申请号：US559001

    申请日：1990-07-26

    申请人： David H. Lynch

    发明人： David H. Lynch

    IPC分类号： A61K35/14 ,  A61K38/00 ,  A61K39/00 ,  A61P37/00 ,  C12N5/0783

    CPC分类号： A61K39/0011 ,  A61K38/2046 ,  C12N5/0636 ,  A61K2039/5158 ,  C12N2501/23

    摘要： There is disclosed an immunotherapy method for treating an individual with cancer or a viral infection comprising obtaining lymphoid cells previously exposed to a specific antigen, culturing the lymphoid cells ex vivo in a culture medium containing an effective amount of an IL-7 polypeptide or a functional derivative thereof to induce CTL activity in the lymphoid cells and administering the lymphoid cells having CTL activity for cells displaying the specific antigen to an individual.

    摘要翻译： 公开了用于治疗患有癌症或病毒感染的个体的免疫治疗方法，包括获得先前暴露于特定抗原的淋巴细胞，在含有有效量的IL-7多肽或功能性的培养基中离体培养淋巴细胞 其在淋巴细胞中诱导CTL活性，并且向个体施用对显示特异性抗原的细胞具有CTL活性的淋巴样细胞。