Invention Grant
- Patent Title: Method of making a protein polymer and uses of the polymer
- Patent Title (中): 制备蛋白质聚合物的方法和聚合物的用途
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Application No.: US09997807Application Date: 2001-11-30
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Publication No.: US07459172B2Publication Date: 2008-12-02
- Inventor: Jay Short , Eric J. Mathur , W. Michael Lafferty , Nelson Barton , Kevin Chow
- Applicant: Jay Short , Eric J. Mathur , W. Michael Lafferty , Nelson Barton , Kevin Chow
- Applicant Address: US CA San Diego
- Assignee: Verenium Corporation
- Current Assignee: Verenium Corporation
- Current Assignee Address: US CA San Diego
- Agency: Morrison & Foerster LLP
- Main IPC: A61K31/74
- IPC: A61K31/74 ; A61K38/16

Abstract:
A polymer is prepared by self-assembly of a plurality of monomeric polypeptide units. The polymer tends to form a nanotube and is capable of encapsulating a particular drug molecule. Once encapsulated in the polymer of the present invention, the drug molecule may be delivered to a particular location of human body to effectively cure a disease or treat a symptom.Generally, the monomeric polypeptide unit of the present invention has a sequence found in Pyrodictium abyssi, a microorganism that produces an extracellular network having hollow protein tubes, or a sequence substantially identical thereto. The monomeric polypeptide may be mass produced using recombinant biotechnologies and be polymerized into the polymer of the present invention. One or more additional targeting vector may be attached to the monomeric polypeptide unit or the polymer to facilitate the targeting of the drug molecule that may be held there within. The sequence contained in the monomeric polypeptide unit may be further optimized using one or more technique selected from Gene Site Saturation Mutagenesis and GeneReasembly™.
Public/Granted literature
- US20030198681A1 Method of making a protein polymer and uses of the polymer Public/Granted day:2003-10-23
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