-
公开(公告)号：US07459172B2
公开(公告)日：2008-12-02
申请号：US09997807
申请日：2001-11-30
申请人： Jay Short , Eric J. Mathur , W. Michael Lafferty , Nelson Barton , Kevin Chow
发明人： Jay Short , Eric J. Mathur , W. Michael Lafferty , Nelson Barton , Kevin Chow
CPC分类号： B82Y30/00 , A61K9/0092 , A61K9/1274 , C07K14/195
摘要： A polymer is prepared by self-assembly of a plurality of monomeric polypeptide units. The polymer tends to form a nanotube and is capable of encapsulating a particular drug molecule. Once encapsulated in the polymer of the present invention, the drug molecule may be delivered to a particular location of human body to effectively cure a disease or treat a symptom.Generally, the monomeric polypeptide unit of the present invention has a sequence found in Pyrodictium abyssi, a microorganism that produces an extracellular network having hollow protein tubes, or a sequence substantially identical thereto. The monomeric polypeptide may be mass produced using recombinant biotechnologies and be polymerized into the polymer of the present invention. One or more additional targeting vector may be attached to the monomeric polypeptide unit or the polymer to facilitate the targeting of the drug molecule that may be held there within. The sequence contained in the monomeric polypeptide unit may be further optimized using one or more technique selected from Gene Site Saturation Mutagenesis and GeneReasembly™.
摘要翻译： 通过多个单体多肽单元的自组装制备聚合物。 聚合物倾向于形成纳米管并且能够封装特定的药物分子。 一旦包封在本发明的聚合物中，药物分子可以被递送到人体的特定位置以有效治愈疾病或治疗症状。 通常，本发明的单体多肽单元具有在黑腹果蝇（Pyrodictium abyssi）中发现的序列，该菌株产生具有中空蛋白管的细胞外网络或与其基本相同的序列。 单体多肽可以使用重组生物技术大规模生产并聚合成本发明的聚合物。 一个或多个另外的靶向载体可以连接到单体多肽单元或聚合物，以促进可能在其中保持的药物分子的靶向。 可以使用选自Gene Site Saturation Mutagenesis和GeneReasembly TM的一种或多种技术进一步优化单体多肽单元中所含的序列。
-
公开(公告)号：US5801822A
公开(公告)日：1998-09-01
申请号：US796740
申请日：1997-02-06
CPC分类号： G01M11/0278 , G01M11/0207 , G01M11/0221 , G01M11/025
摘要： An ophthalmic lens inspection system includes an illumination assembly which generates diffuse light and transmits the diffuse light through an ophthalmic lens disposed in an inspection position, the diffuse light having a diffusivity of between 30.degree. and 50.degree.. An imaging assembly generates a set of signals representing selected portions of the diffuse light transmitted through the ophthalmic lens in the inspection position. A moving mechanism supports the imaging and illumination assemblies for common movement relative to the contact lens, to bring a reference point into alignment with the center of the imaging assembly.
-
公开(公告)号：US5190028A
公开(公告)日：1993-03-02
申请号：US845070
申请日：1992-03-03
CPC分类号： A61B1/00096 , A61B1/0011 , A61B1/00165 , A61B1/00179 , A61B1/00183 , A61B1/042 , A61B1/317 , A61B46/10 , A61B1/00188 , Y10S600/92
摘要： A method is provided for assembling an arthroscopic probe which includes bending a linear image-transmitting optical fiber about a heated pivot point so that the distal end of the fiber is oblique to the proximal end. A lens is then attached to the distal face of the image-transmitting optical fiber by means of an adhesive and the resulting image path is positioned in a hollow needle with the lens exposed at the distal end and the optical fiber exposed at the proximal end. An illuminating optical fiber is also positioned in the needle adjacent the image path and the two are anchored therein by a curable filler material. Finally, the needle is proximally mounted in a base such that the proximal faces of the image-transmitting and illuminating optical fibers are exposed.
摘要翻译： 提供了一种用于组装关节镜探针的方法，该方法包括将线性图像传输光纤围绕加热的枢转点弯曲，使得光纤的远端相对于近端倾斜。 然后通过粘合剂将透镜附接到图像传输光纤的远侧面，并且所得到的图像路径被定位在中空针中，其中透镜在远端露出并且光纤在近端露出。 照明光纤也位于邻近图像路径的针中，并且两者通过可固化填充材料锚固在其中。 最后，将针向近侧安装在底座中，使得图像传输和照射光纤的近端面露出。
-
4.发明申请Method and Apparatus for Addressable Flow Cells in Single Molecule Sequencing 审中-公开单分子测序中可寻址流动池的方法和装置公开(公告)号：US20110311963A1
公开(公告)日：2011-12-22
申请号：US13049660
申请日：2011-03-16
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q2523/319 , C12Q2525/186 , C12Q2565/513
摘要： A method of sequencing a plurality of template nucleotide sequences includes immobilizing the plurality of template nucleotide sequences on a substrate. A first subset of the plurality of template nucleotide sequences is immobilized in a first field of view and a second subset of the plurality of template nucleotide sequences is immobilized in a second field of view. The first and second subsets are hybridized to a caged primer. The caged primer includes a caging group. The method further includes lysing the caging group from the caged primer in the first field of view and observing the first field of view to detect sequencing of the first subset of the plurality of template nucleotide sequences.
摘要翻译： 对多个模板核苷酸序列进行测序的方法包括将多个模板核苷酸序列固定在底物上。 多个模板核苷酸序列的第一子集被固定在第一视场中，并且多个模板核苷酸序列的第二子集被固定在第二视野中。 第一和第二子集与笼式引物杂交。 笼状引物包括笼养组。 该方法还包括在第一视场中从笼式引物裂解笼基组，并观察第一视野以检测多个模板核苷酸序列的第一子集的测序。
-
公开(公告)号：US5818573A
公开(公告)日：1998-10-06
申请号：US796744
申请日：1997-02-06
CPC分类号： G01M11/0221
摘要： An ophthalmic lens inspection system includes an illumination assembly which generates diffuse light and transmits the diffuse light through an ophthalmic lens disposed in an inspection position, the diffuse light having a diffusivity of between 30.degree. and 50.degree.. An imaging assembly generates a set of signals representing selected portions of the diffuse light transmitted through the ophthalmic lens in the inspection position. A moving mechanism supports the imaging and illumination assemblies for common movement relative to the contact lens, to bring a reference point into alignment with the center of the imaging assembly.
摘要翻译： 一种眼科镜检查系统，包括产生漫射光并通过设置在检查位置的眼镜透射漫射光的照明组件，扩散光的扩散系数在30°至50°之间。 成像组件在检查位置产生表示通过眼科镜片透射的漫射光的所选部分的一组信号。 移动机构支持用于相对于隐形眼镜共同移动的成像和照明组件，以使参考点与成像组件的中心对准。
-
6.发明申请CHIMERIC CANNULAE PROTEINS AND METHODS FOR MAKING AND USING THEM 审中-公开CHIMERIC CANNULAE蛋白质及其制备和使用方法公开(公告)号：US20100172968A1
公开(公告)日：2010-07-08
申请号：US11929781
申请日：2007-10-30
申请人： Jay Short , Eric J. Mathur , W. Michael Lafferty , Nelson Barton , Kevin Chow
发明人： Jay Short , Eric J. Mathur , W. Michael Lafferty , Nelson Barton , Kevin Chow
CPC分类号： B82Y30/00 , A61K9/0092 , A61K9/1274 , C07K14/195
摘要： A polymer is prepared by self-assembly of a plurality of monomeric polypeptide units. The polymer tends to form a nanotube and is capable of encapsulating a particular drug molecule. Once encapsulated in the polymer of the present invention, the drug molecule may be delivered to a particular location of human body to effectively cure a disease or treat a symptom.Generally, the monomeric polypeptide unit of the present invention has a sequence found in Pyrodictium abyssi, a microorganism that produces an extracellular network having hollow protein tubes, or a sequence substantially identical thereto. The monomeric polypeptide may be mass produced using recombinant biotechnologies and be polymerized into the polymer of the present invention. One or more additional targeting vector may be attached to the monomeric polypeptide unit or the polymer to facilitate the targeting of the drug molecule that may be held there within. The sequence contained in the monomeric polypeptide unit may be further optimized using one or more technique selected from Gene Site Saturation Mutagenesis and GeneReasembly.
摘要翻译： 通过多个单体多肽单元的自组装制备聚合物。 聚合物倾向于形成纳米管并且能够封装特定的药物分子。 一旦包封在本发明的聚合物中，药物分子可以被递送到人体的特定位置以有效治愈疾病或治疗症状。 通常，本发明的单体多肽单元具有在黑腹果蝇（Pyrodictium abyssi）中发现的序列，该菌株产生具有中空蛋白管的细胞外网络或与其基本相同的序列。 单体多肽可以使用重组生物技术大规模生产并聚合成本发明的聚合物。 一个或多个另外的靶向载体可以连接到单体多肽单元或聚合物，以促进可能在其中保持的药物分子的靶向。 可以使用选自基因位点饱和诱变和基因重组的一种或多种技术进一步优化单体多肽单元中所含的序列。
-
公开(公告)号：US5301657A
公开(公告)日：1994-04-12
申请号：US932957
申请日：1992-08-21
CPC分类号： A61B1/317 , A61B1/00096 , A61B1/00165 , A61B1/00179 , A61B1/00183 , A61B1/042 , A61B1/055 , A61B46/10 , A61B1/00188
摘要： A disposable sterile sleeve is provided which is removably attachable to a video camera of an arthroscope. The sleeve comprises a flexible elongate tubular shroud and a rigid annular mounting collar. The shroud is open ended with the collar rotatably attached to one open end by a connector member providing independent rotation of the collar relative to the shroud. A pull tab is attached to the opposite open end of the shroud to facilitate extension of the shroud over the camera. The sleeve may be compacted for storage prior to use by tightly scrunching the shroud together, thereby folding it onto itself. To attach the sleeve to the camera, the video camera is inserted through the compacted shroud until it engages the collar. A male thread provided on the camera is threaded into a female thread provided on the collar and the shroud is then extended over the camera by pulling on the tab to draw out the folds in the shroud.
摘要翻译： 提供了可拆卸地附接到关节镜的摄像机的一次性无菌套筒。 套筒包括柔性细长管状护罩和刚性环形安装套环。 护罩是开口的，其中套环通过连接器构件可旋转地附接到一个开口端，从而提供套环相对于护罩的独立旋转。 拉片连接到护罩的相对的开口端，以便将护罩延伸到相机上。 在使用之前，可以将套筒压紧以将其保持在一起，从而将其折叠到其上。 要将套筒连接到相机上，摄像机将插入通过压缩的护罩，直到其接合套环。 设置在相机上的外螺纹被拧入提供在轴环上的阴螺纹中，然后通过拉动突片以将护罩拉出，从而将护罩延伸穿过相机。
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.021 秒)
