Invention Grant
US07498424B2 Nucleic acids encoding a novel influenza virus non-structural protein (NS1)-binding host factor designated NS1I-1
有权
编码新型流感病毒非结构蛋白（NS1）结合宿主因子的指定NS1I-1的核酸
- Patent Title: Nucleic acids encoding a novel influenza virus non-structural protein (NS1)-binding host factor designated NS1I-1
- Patent Title (中): 编码新型流感病毒非结构蛋白（NS1）结合宿主因子的指定NS1I-1的核酸
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Application No.: US10724273Application Date: 2003-11-24
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Publication No.: US07498424B2Publication Date: 2009-03-03
- Inventor: Peter Palese , Robert O'Neill
- Applicant: Peter Palese , Robert O'Neill
- Applicant Address: US NY New York
- Assignee: Mount Sinai School of Medicine of New York University
- Current Assignee: Mount Sinai School of Medicine of New York University
- Current Assignee Address: US NY New York
- Agency: Jones Day
- Main IPC: C07H21/02
- IPC: C07H21/02
Abstract:
The present invention relates to the identification of host cell proteins that interact with viral proteins required for virus replication, and high throughput assays to identify compounds that interfere with the specific interaction between the viral and host cell protein. Interfering compounds that inhibit viral replication can be used therapeutically to treat viral infection.The invention is based, in part, on the Applicants' discovery of novel interactions between proteins of the influenza virus and a human host cell proteins. One of these host cell proteins, referred to herein as NPI-1, interacts with influenza virus protein NP, and may be an accessory protein required for replication of influenza virus. Another of these host cell proteins, referred to herein as NS1I-1, interacts with influenza virus protein NS1. Compounds that interfere with the binding of the host cell and viral proteins, and inhibit viral replication can be useful for treating viral infection in vivo.
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