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    Identification and use of antiviral compounds that inhibit interaction of host cell proteins and viral proteins required for viral replication
    1.
    发明授权
    Identification and use of antiviral compounds that inhibit interaction of host cell proteins and viral proteins required for viral replication 失效
    鉴定和使用抑制病毒复制所需的宿主细胞蛋白和病毒蛋白相互作用的抗病毒化合物

    公开(公告)号：US5750394A

    公开(公告)日：1998-05-12

    申请号：US246583

    申请日：1994-05-20

    Applicant: Peter Palese ,  Robert O'Neill

    Inventor： Peter Palese ,  Robert O'Neill

    IPC: G01N33/566 ,  A61K38/00 ,  A61P31/12 ,  C07K14/47 ,  C12N1/21 ,  C12N15/09 ,  C12P21/02 ,  C12Q1/70 ,  C12R1/19 ,  G01N33/50 ,  G01N33/569 ,  C07H21/04 ,  C12N5/10 ,  C12N15/63

    CPC classification number: G01N33/502 ,  C07K14/4703 ,  C12Q1/70 ,  G01N33/5008 ,  G01N33/56983 ,  G01N2333/11 ,  G01N2500/20

    Abstract: The present invention relates to the identification of host cell proteins that interact with viral proteins required for virus replication, and high throughput assays to identify compounds that interfere with the specific interaction between the viral and host cell protein. Interfering compounds that inhibit viral replication can be used therapeutically to treat viral infection. The invention is based, in part, on the discovery described herein of a novel interaction between the NP of influenza virus and a human host cell protein. The host cell protein, referred to herein as NPI-1, may be an accessory protein required for replication of influenza virus. Compounds that interfere with the binding of the host cell and viral proteins, and inhibit viral replication can be useful for treating viral infection in vivo.

    Abstract translation: 本发明涉及鉴定与病毒复制所需的病毒蛋白相互作用的宿主细胞蛋白质，以及用于鉴定干扰病毒和宿主细胞蛋白质之间特异性相互作用的化合物的高通量测定。 抑制病毒复制的干扰化合物可用于治疗性治疗病毒感染。 本发明部分地基于本文所述的流感病毒的NP与人宿主细胞蛋白之间的新的相互作用的发现。 本文称为NPI-1的宿主细胞蛋白可以是复制流感病毒所需的辅助蛋白质。 干扰宿主细胞和病毒蛋白结合并抑制病毒复制的化合物可用于在体内治疗病毒感染。

    Identification and use of antiviral compounds that inhibit interaction of host cell proteins and viral proteins required for viral replication
    2.
    发明申请
    Identification and use of antiviral compounds that inhibit interaction of host cell proteins and viral proteins required for viral replication 有权
    鉴定和使用抑制病毒复制所需的宿主细胞蛋白和病毒蛋白相互作用的抗病毒化合物

    公开(公告)号：US20050191703A1

    公开(公告)日：2005-09-01

    申请号：US10724273

    申请日：2003-11-24

    Applicant: Peter Palese ,  Robert O'Neill

    Inventor： Peter Palese ,  Robert O'Neill

    IPC: G01N33/566 ,  A61K38/00 ,  A61P31/12 ,  C07K14/47 ,  C12N1/21 ,  C12N15/09 ,  C12P21/02 ,  C12Q1/70 ,  C12R1/19 ,  G01N33/50 ,  G01N33/569 ,  C12Q1/68 ,  C12P21/06 ,  G01N33/53

    CPC classification number: G01N33/502 ,  C07K14/4703 ,  C12Q1/70 ,  G01N33/5008 ,  G01N33/56983 ,  G01N2333/11 ,  G01N2500/20

    Abstract: The present invention relates to the identification of host cell proteins that interact with viral proteins required for virus replication, and high throughput assays to identify compounds that interfere with the specific interaction between the viral and host cell protein. Interfering compounds that inhibit viral replication can be used therapeutically to treat viral infection. The invention is based, in part, on the Applicants' discovery of novel interactions between proteins of the influenza virus and a human host cell proteins. One of these host cell proteins, referred to herein as NPI-1, interacts with influenza virus protein NP, and may be an accessory protein required for replication of influenza virus. Another of these host cell proteins, referred to herein as NS1I-1, interacts with influenza virus protein NS1. Compounds that interfere with the binding of the host cell and viral proteins, and inhibit viral replication can be useful for treating viral infection in vivo.

    Abstract translation: 本发明涉及鉴定与病毒复制所需的病毒蛋白相互作用的宿主细胞蛋白质，以及用于鉴定干扰病毒和宿主细胞蛋白质之间特异性相互作用的化合物的高通量测定。 抑制病毒复制的干扰化合物可用于治疗性治疗病毒感染。 本发明部分地基于申请人发现流感病毒的蛋白质与人宿主细胞蛋白质之间的新的相互作用。 这些宿主细胞蛋白之一，本文称为NPI-1，与流感病毒蛋白NP相互作用，并且可能是复制流感病毒所需的辅助蛋白。 这些宿主细胞蛋白质（本文称为NS1I-1）中的另一种与流感病毒蛋白NS1相互作用。 干扰宿主细胞和病毒蛋白结合并抑制病毒复制的化合物可用于在体内治疗病毒感染。

    Nucleic acids encoding a novel influenza virus non-structural protein (NS1)-binding host factor designated NS1I-1
    4.
    发明授权
    Nucleic acids encoding a novel influenza virus non-structural protein (NS1)-binding host factor designated NS1I-1 有权
    编码新型流感病毒非结构蛋白（NS1）结合宿主因子的指定NS1I-1的核酸

    公开(公告)号：US07498424B2

    公开(公告)日：2009-03-03

    申请号：US10724273

    申请日：2003-11-24

    Applicant: Peter Palese ,  Robert O'Neill

    Inventor： Peter Palese ,  Robert O'Neill

    IPC: C07H21/02

    CPC classification number: G01N33/502 ,  C07K14/4703 ,  C12Q1/70 ,  G01N33/5008 ,  G01N33/56983 ,  G01N2333/11 ,  G01N2500/20

    Abstract: The present invention relates to the identification of host cell proteins that interact with viral proteins required for virus replication, and high throughput assays to identify compounds that interfere with the specific interaction between the viral and host cell protein. Interfering compounds that inhibit viral replication can be used therapeutically to treat viral infection.The invention is based, in part, on the Applicants' discovery of novel interactions between proteins of the influenza virus and a human host cell proteins. One of these host cell proteins, referred to herein as NPI-1, interacts with influenza virus protein NP, and may be an accessory protein required for replication of influenza virus. Another of these host cell proteins, referred to herein as NS1I-1, interacts with influenza virus protein NS1. Compounds that interfere with the binding of the host cell and viral proteins, and inhibit viral replication can be useful for treating viral infection in vivo.

    Abstract translation: 本发明涉及鉴定与病毒复制所需的病毒蛋白相互作用的宿主细胞蛋白，以及用于鉴定干扰病毒和宿主细胞蛋白之间特异性相互作用的化合物的高通量测定。 抑制病毒复制的干扰化合物可用于治疗性治疗病毒感染。 本发明部分地基于申请人发现流感病毒的蛋白质与人宿主细胞蛋白质之间的新的相互作用。 这些宿主细胞蛋白之一，本文称为NPI-1，与流感病毒蛋白NP相互作用，并且可能是复制流感病毒所需的辅助蛋白。 这些宿主细胞蛋白质（本文称为NS1I-1）中的另一种与流感病毒蛋白NS1相互作用。 干扰宿主细胞和病毒蛋白结合并抑制病毒复制的化合物可用于在体内治疗病毒感染。

    Influenza viruses and uses thereof
    6.
    发明授权
    Influenza viruses and uses thereof 有权
    流感病毒及其用途

    公开(公告)号：US08828406B2

    公开(公告)日：2014-09-09

    申请号：US13387485

    申请日：2010-07-29

    Applicant: Adolfo Garcia-Sastre ,  Peter Palese ,  Qinshan Gao

    Inventor： Adolfo Garcia-Sastre ,  Peter Palese ,  Qinshan Gao

    IPC: A61K39/145 ,  C12N7/04 ,  C12N7/02 ,  A61P37/04 ,  C12N7/01 ,  C12N15/44 ,  C07K14/005 ,  C12N7/00 ,  A61K39/00

    CPC classification number: C07K14/005 ,  A61K2039/525 ,  A61K2039/5254 ,  C12N7/00 ,  C12N2760/16122 ,  C12N2760/16162 ,  C12N2760/16222 ,  C12N2760/16262

    Abstract: Described herein are chimeric influenza virus gene segments and nucleic acid sequences encoding such chimeric influenza virus gene segments. A chimeric influenza virus gene segment described herein comprises packaging signals found in the non-coding and coding regions of one type of influenza virus gene segment and an open reading frame of a different type of influenza virus gene segment or fragment thereof. Also described herein are recombinant influenza viruses comprising two or more chimeric influenza virus gene segments and the use of such viruses in the prevention and/or treatment of influenza virus disease.

    Abstract translation: 本文描述的是嵌合流感病毒基因片段和编码这种嵌合型流感病毒基因片段的核酸序列。 本文描述的嵌合型流感病毒基因片段包括在一种类型的流感病毒基因片段的非编码和编码区以及不同类型的流感病毒基因片段或其片段的开放阅读框中发现的包装信号。 本文还描述了包含两种或更多种嵌合型流感病毒基因区段的重组流感病毒以及这种病毒在预防和/或治疗流感病毒疾病中的用途。

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