公开(公告)号：US20120175315A1

公开(公告)日：2012-07-12

申请号：US13496176

申请日：2010-04-22

Applicant: Adrian Peter Revington ,  Oladipo Omotoso ,  Patrick Sean Wells ,  Thomas Charles Hann ,  Marvin Harvey Weiss ,  Trevor Bugg ,  Jamie Eastwood ,  Stephen Joseph Young ,  Hugues Robert O'Neill ,  Ana Cristina Sanchez

Inventor： Adrian Peter Revington ,  Oladipo Omotoso ,  Patrick Sean Wells ,  Thomas Charles Hann ,  Marvin Harvey Weiss ,  Trevor Bugg ,  Jamie Eastwood ,  Stephen Joseph Young ,  Hugues Robert O'Neill ,  Ana Cristina Sanchez

IPC: B01D21/01 ,  B01D21/24 ,  C02F1/52

CPC classification number: C10G1/047 ,  B01F5/0463 ,  B01F5/0466 ,  B01F2005/0034 ,  C02F1/56 ,  C02F11/14 ,  C02F2103/10 ,  C10G33/04

Abstract: A process for dewatering oil sand fine tailings is provided and comprises a dispersion and floc build-up stage comprising in-line addition of a flocculent solution comprising an effective amount of flocculation reagent into a flow of the oil sand fine tailings; a gel stage wherein flocculated oil sand fine tailings is transported in-line and subjected to shear conditioning; a floc breakdown and water release stage wherein the flocculated oil sand fine tailings releases water and decreases in yield shear stress, while avoiding an oversheared zone; depositing the flocculated oil sand fine tailings onto a deposition area to form a deposit and to enable the release water to flow away from the deposit, preferably done in a pipeline reactor and managing shear according to yield stress and CST information and achieves enhanced dewatering.

Abstract translation: 提供了一种用于脱砂油砂细尾矿的方法，包括分散和絮凝物堆积阶段，包括将含有效量的絮凝试剂的絮状溶液直列添加到油砂细尾矿的流中; 其中絮凝油砂细尾矿在线输送并进行剪切调节的凝胶阶段; 絮凝破碎和放水阶段，其中絮凝油砂细尾矿释放水分并降低产量剪切应力，同时避免过度磨损区域; 将絮凝的油砂细尾矿沉积到沉积区域上以形成沉积物，并使释放水能够远离沉积物，优选在管道反应器中进行，并根据屈服应力和CST信息进行剪切，并实现增强的脱水。

公开(公告)号：US20060208565A1

公开(公告)日：2006-09-21

申请号：US11081437

申请日：2005-03-16

Applicant: Robert O'Neill

Inventor： Robert O'Neill

IPC: B60T7/00

CPC classification number: B60T13/74 ,  B60T8/325 ,  B64C25/42

Abstract: A brake assembly includes a mounting plate, pressure members disposed in a substantially coplanar manner relative to the mounting plate, and electric actuators mounted to the mounting plate. The electric actuators are configured to selectively move the pressure members relative to the mounting plate (i) from a non-braking position to a braking position in response to a first command, and (ii) from the braking position to the non-braking position in response to a second command. Such a brake assembly is well-suited for a variety of applications including vehicle brakes such as aircraft brakes.

Abstract translation: 制动组件包括安装板，相对于安装板以基本共面的方式设置的压力构件以及安装到安装板的电致动器。 电动执行器构造成响应于第一命令，将压力构件相对于安装板（i）选择性地从非制动位置移动到制动位置，并且（ii）从制动位置到非制动位置 响应于第二个命令。 这种制动组件非常适用于各种应用，包括诸如飞机制动器的车辆制动器。

公开(公告)号：US5750394A

公开(公告)日：1998-05-12

申请号：US246583

申请日：1994-05-20

Applicant: Peter Palese ,  Robert O'Neill

Inventor： Peter Palese ,  Robert O'Neill

IPC: G01N33/566 ,  A61K38/00 ,  A61P31/12 ,  C07K14/47 ,  C12N1/21 ,  C12N15/09 ,  C12P21/02 ,  C12Q1/70 ,  C12R1/19 ,  G01N33/50 ,  G01N33/569 ,  C07H21/04 ,  C12N5/10 ,  C12N15/63

CPC classification number: G01N33/502 ,  C07K14/4703 ,  C12Q1/70 ,  G01N33/5008 ,  G01N33/56983 ,  G01N2333/11 ,  G01N2500/20

Abstract: The present invention relates to the identification of host cell proteins that interact with viral proteins required for virus replication, and high throughput assays to identify compounds that interfere with the specific interaction between the viral and host cell protein. Interfering compounds that inhibit viral replication can be used therapeutically to treat viral infection. The invention is based, in part, on the discovery described herein of a novel interaction between the NP of influenza virus and a human host cell protein. The host cell protein, referred to herein as NPI-1, may be an accessory protein required for replication of influenza virus. Compounds that interfere with the binding of the host cell and viral proteins, and inhibit viral replication can be useful for treating viral infection in vivo.

Abstract translation: 本发明涉及鉴定与病毒复制所需的病毒蛋白相互作用的宿主细胞蛋白质，以及用于鉴定干扰病毒和宿主细胞蛋白质之间特异性相互作用的化合物的高通量测定。 抑制病毒复制的干扰化合物可用于治疗性治疗病毒感染。 本发明部分地基于本文所述的流感病毒的NP与人宿主细胞蛋白之间的新的相互作用的发现。 本文称为NPI-1的宿主细胞蛋白可以是复制流感病毒所需的辅助蛋白质。 干扰宿主细胞和病毒蛋白结合并抑制病毒复制的化合物可用于在体内治疗病毒感染。

公开(公告)号：US2302884A

公开(公告)日：1942-11-24

申请号：US42663242

申请日：1942-01-13

Applicant: ROBERT O'NEILL

Inventor： ROBERT O'NEILL

IPC: G01F23/04

CPC classification number: G01F23/04

公开(公告)号：US07498424B2

公开(公告)日：2009-03-03

申请号：US10724273

申请日：2003-11-24

Applicant: Peter Palese ,  Robert O'Neill

Inventor： Peter Palese ,  Robert O'Neill

IPC: C07H21/02

CPC classification number: G01N33/502 ,  C07K14/4703 ,  C12Q1/70 ,  G01N33/5008 ,  G01N33/56983 ,  G01N2333/11 ,  G01N2500/20

Abstract: The present invention relates to the identification of host cell proteins that interact with viral proteins required for virus replication, and high throughput assays to identify compounds that interfere with the specific interaction between the viral and host cell protein. Interfering compounds that inhibit viral replication can be used therapeutically to treat viral infection.The invention is based, in part, on the Applicants' discovery of novel interactions between proteins of the influenza virus and a human host cell proteins. One of these host cell proteins, referred to herein as NPI-1, interacts with influenza virus protein NP, and may be an accessory protein required for replication of influenza virus. Another of these host cell proteins, referred to herein as NS1I-1, interacts with influenza virus protein NS1. Compounds that interfere with the binding of the host cell and viral proteins, and inhibit viral replication can be useful for treating viral infection in vivo.

Abstract translation: 本发明涉及鉴定与病毒复制所需的病毒蛋白相互作用的宿主细胞蛋白，以及用于鉴定干扰病毒和宿主细胞蛋白之间特异性相互作用的化合物的高通量测定。 抑制病毒复制的干扰化合物可用于治疗性治疗病毒感染。 本发明部分地基于申请人发现流感病毒的蛋白质与人宿主细胞蛋白质之间的新的相互作用。 这些宿主细胞蛋白之一，本文称为NPI-1，与流感病毒蛋白NP相互作用，并且可能是复制流感病毒所需的辅助蛋白。 这些宿主细胞蛋白质（本文称为NS1I-1）中的另一种与流感病毒蛋白NS1相互作用。 干扰宿主细胞和病毒蛋白结合并抑制病毒复制的化合物可用于在体内治疗病毒感染。

公开(公告)号：US06503703B1

公开(公告)日：2003-01-07

申请号：US09636791

申请日：2000-08-11

Applicant: Peter M Palese ,  Robert O'Neill ,  Ronald Harty

Inventor： Peter M Palese ,  Robert O'Neill ,  Ronald Harty

IPC: C12Q100

CPC classification number: C07K14/005 ,  A61K38/00 ,  C12N15/1055 ,  C12N2760/16122 ,  G01N33/56983 ,  G01N2333/11

Abstract: The present invention relates to the identification of host cell proteins that interact with viral proteins required for virus replication, and high throughput assays to identify compounds that interfere with the specific interaction between the viral and host cell protein. Interfering compounds that inhibit viral replication can be used therapeutically to treat viral infection. The invention is based, in part, on the Applicants' discovery of novel interactions between viral proteins and a human host cell proteins. One of these host cell proteins, referred to herein as NPI-1, interacts with influenza virus protein NP. Also, host cell proteins, referred to herein as NS1I-1 and NS1-BP interact with influenza virus protein NS1. In addition, host cell proteins containing WW domains that interact with viral proteins such as Rhabdoviral M protein are described. Compounds that interfere with the binding of the host cell and viral proteins, and inhibit viral replication can be useful for treating viral infection in vivo.

公开(公告)号：US20130081298A1

公开(公告)日：2013-04-04

申请号：US13505228

申请日：2009-10-30

Applicant: Trevor Bugg ,  Jamie Eastwood ,  Adrian Peter Revington ,  Marvin Harvey Weiss ,  Patrick Sean Wells ,  Thomas Charles Hann ,  Stephen Joseph Young ,  Hugues Robert O'Neill

Inventor： Trevor Bugg ,  Jamie Eastwood ,  Adrian Peter Revington ,  Marvin Harvey Weiss ,  Patrick Sean Wells ,  Thomas Charles Hann ,  Stephen Joseph Young ,  Hugues Robert O'Neill

IPC: F26B7/00

CPC classification number: F26B7/00 ,  B09C1/08 ,  F26B5/00 ,  F26B2200/14

Abstract: Methods for drying oil sand fine tailings treated to comprise flocculated fine tailings, by deposition and farming techniques, are provided. A deposition cell is provided with a sloped bottom surface and the flocculated fine tailings are deposited to undergo channelless advancement in the cell while allowing drainage of release water. When the deposit is uneven, the deposit may be plowed while wet for spreading and ensuring water release conditioning is imparted thereto, while avoiding over-shearing, and maintaining sufficient shear strength to allow standing. Once a dried upper crust forms, the deposit may be harrowed to break up the crust, expose wet regions there-beneath and create furrows in the standing deposit. The methods improve the dewatering and drying of mature fine tailings in oil sands.

Abstract translation: 提供了通过沉积和养殖技术干燥处理包含絮凝细尾矿的油砂细尾矿的方法。 沉积池设置有倾斜的底表面，并且沉积絮凝的细尾矿以在池中进行无通道前进，同时允许排放水。 当沉积物不均匀时，沉积物可以在湿润地铺展并且确保给水释放调节，同时避免过度剪切，并保持足够的剪切强度以允许静置。 一旦形成干燥的上部地壳，沉积物可能会受到破坏，从而破坏地壳，暴露在其下方的潮湿区域，并在立方沉积物中形成沟槽。 该方法改善了油砂成熟细尾矿的脱水和干燥。

公开(公告)号：US20050191703A1

公开(公告)日：2005-09-01

申请号：US10724273

申请日：2003-11-24

Applicant: Peter Palese ,  Robert O'Neill

Inventor： Peter Palese ,  Robert O'Neill

IPC: G01N33/566 ,  A61K38/00 ,  A61P31/12 ,  C07K14/47 ,  C12N1/21 ,  C12N15/09 ,  C12P21/02 ,  C12Q1/70 ,  C12R1/19 ,  G01N33/50 ,  G01N33/569 ,  C12Q1/68 ,  C12P21/06 ,  G01N33/53

CPC classification number: G01N33/502 ,  C07K14/4703 ,  C12Q1/70 ,  G01N33/5008 ,  G01N33/56983 ,  G01N2333/11 ,  G01N2500/20

Abstract: The present invention relates to the identification of host cell proteins that interact with viral proteins required for virus replication, and high throughput assays to identify compounds that interfere with the specific interaction between the viral and host cell protein. Interfering compounds that inhibit viral replication can be used therapeutically to treat viral infection. The invention is based, in part, on the Applicants' discovery of novel interactions between proteins of the influenza virus and a human host cell proteins. One of these host cell proteins, referred to herein as NPI-1, interacts with influenza virus protein NP, and may be an accessory protein required for replication of influenza virus. Another of these host cell proteins, referred to herein as NS1I-1, interacts with influenza virus protein NS1. Compounds that interfere with the binding of the host cell and viral proteins, and inhibit viral replication can be useful for treating viral infection in vivo.

Abstract translation: 本发明涉及鉴定与病毒复制所需的病毒蛋白相互作用的宿主细胞蛋白质，以及用于鉴定干扰病毒和宿主细胞蛋白质之间特异性相互作用的化合物的高通量测定。 抑制病毒复制的干扰化合物可用于治疗性治疗病毒感染。 本发明部分地基于申请人发现流感病毒的蛋白质与人宿主细胞蛋白质之间的新的相互作用。 这些宿主细胞蛋白之一，本文称为NPI-1，与流感病毒蛋白NP相互作用，并且可能是复制流感病毒所需的辅助蛋白。 这些宿主细胞蛋白质（本文称为NS1I-1）中的另一种与流感病毒蛋白NS1相互作用。 干扰宿主细胞和病毒蛋白结合并抑制病毒复制的化合物可用于在体内治疗病毒感染。

公开(公告)号：US5701356A

公开(公告)日：1997-12-23

申请号：US567154

申请日：1995-12-05

Applicant: Thomas H. Stanford ,  Farhad Noroozi Sahne ,  Thomas P. Riches ,  Robert O'Neill

Inventor： Thomas H. Stanford ,  Farhad Noroozi Sahne ,  Thomas P. Riches ,  Robert O'Neill

IPC: H04R5/02 ,  H04R25/00

CPC classification number: H04R5/023

Abstract: The transducer support assembly includes a transducer secured to a U-shaped strap having a pair of chest engageable leg portions connected integrally to a curved neck engageable portion by a pair of twisted intermediate portions for engaging the body of the user. The chest engageable leg portions are adapted to fit over the shoulders and to lie substantially flat against the chest of the user. A wide portion of the neck engageable portion extends in overlying substantially continuous engagement with the neck or back of the user to resist the chest engageable leg portions from swinging away from the chest. A gripping material forms an underside surface of the strap to frictionally engage the user, thereby inhibiting the strap from moving relative to the body of the user. Another transducer support assembly includes a flexible U-shaped neck support having a chest engageable portion. A transducer secured within a transducer support is coupled slidably to the chest engageable portion to enable it to be selectively positioned relative to the chest engageable portion.

Abstract translation: 传感器支撑组件包括固定到U形带的换能器，该U形带具有一对胸部可接合的腿部，通过一对扭转的中间部分一体地连接到弯曲的颈部可接合部分，用于接合使用者的身体。 胸部可接合的腿部适于装配在肩部上并且基本上平坦地抵靠使用者的胸部。 颈部可接合部分的大部分以覆盖与使用者的颈部或背部的基本上连续的接合方式延伸，以抵抗胸部可接合的腿部部分远离胸部摆动。 夹持材料形成带的下表面以摩擦地接合使用者，从而阻止带相对于使用者的身体移动。 另一换能器支撑组件包括具有胸部可接合部分的柔性U形颈部支撑件。 固定在换能器支撑件内的换能器可滑动地联接到胸部可接合部分，以使其相对于胸部可接合部分被选择性地定位。

公开(公告)号：US5448235A

公开(公告)日：1995-09-05

申请号：US116592

申请日：1993-08-30

Applicant: Robert O'Neill, Jr. ,  Judith B. Snow

Inventor： Robert O'Neill, Jr. ,  Judith B. Snow

IPC: B63B45/02 ,  G08G3/00

CPC classification number: B63B45/02 ,  G08G3/00

Abstract: A method and system are provided for marking marine channels. A single laser beam is selectively interrupted to produce an identifying on/off laser beam sequence distinguishable by the human eye. The laser beam is then expanded in terms of beam diameter during specifically timed periods of laser beam transmission. The expanded laser beam is projected along a beam path that is substantially along the center of a marine channel to be marked at a height above the water's surface. The height of the beam path is selected such that marine traffic may pass under the beam path without obstructing same.

Abstract translation: 提供了一种用于标记海洋通道的方法和系统。 选择性地中断单个激光束以产生由人眼可辨别的识别开/关激光束序列。 然后在激光束传输的特定定时周期期间，根据光束直径来扩大激光束。 扩大的激光束沿着大致沿着海洋通道的中心的光束路径投影，以在水表面上方的高度被标记。 选择光束路径的高度，使得海上交通可以在光束路径下方通过而不会妨碍。