发明授权
- 专利标题： Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions
- 专利标题（中）： 6位取代的吲哚啉酮衍生物及其制备及其作为药物组合物的用途
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申请号： US10624983申请日： 2003-07-22
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公开(公告)号： US07514468B2公开(公告)日： 2009-04-07
- 发明人: Armin Heckel , Frank Hilberg , Thorsten Lehmann-Lintz , Guenter Linz , Joerg Kley , Jacobus C. A. Van Meel , Werner Rall , Gerald Juergen Roth , Peter Sieger , Ulrike Tontsch-Grunt
- 申请人： Armin Heckel , Frank Hilberg , Thorsten Lehmann-Lintz , Guenter Linz , Joerg Kley , Jacobus C. A. Van Meel , Werner Rall , Gerald Juergen Roth , Peter Sieger , Ulrike Tontsch-Grunt
- 申请人地址： DE Ingelheim
- 专利权人： Boehringer Ingelheim Pharma GmbH & Co. KG
- 当前专利权人： Boehringer Ingelheim Pharma GmbH & Co. KG
- 当前专利权人地址： DE Ingelheim
- 代理商 Michael P. Morris; Mary-Ellen M. Devlin; Timothy X. Witkowski
- 优先权： DE10233366 20020723
- 主分类号： A61K31/404
- IPC分类号： A61K31/404 ; C07D209/34
摘要：
The present invention relates to indolinone derivatives substituted in the 6 position of general formula wherein R1 to R6 and X are defined as in claim 1, the tautomers, enantiomers, diastereomers, mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof, which have valuable pharmacological properties, in particular an inhibiting effect on various receptor tyrosine kinases and on the proliferation of endothelial cells and various tumour cells, pharmaceutical compositions containing these compounds, their use and processes for preparing them.