发明授权
- 专利标题： Aryl-isoxazolo-4-yl-oxadiazole derivatives
- 专利标题（中）： 芳基异恶唑-4-基 - 恶二唑衍生物
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申请号： US11639695申请日： 2006-12-15
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公开(公告)号： US07541372B2公开(公告)日： 2009-06-02
- 发明人: Bernd Buettelmann , Bo Han , Henner Knust , Andreas Koblet , Andrew Thomas
- 申请人： Bernd Buettelmann , Bo Han , Henner Knust , Andreas Koblet , Andrew Thomas
- 申请人地址： US NJ Nutley
- 专利权人： Hoffman-La Roche Inc.
- 当前专利权人： Hoffman-La Roche Inc.
- 当前专利权人地址： US NJ Nutley
- 代理商 George W. Johnston; Patricia S. Rocha-Tramaloni; Kimberly J. Prior
- 主分类号： A61K31/422
- IPC分类号： A61K31/422 ; A61K31/4245 ; C07D261/06 ; C07D271/07
摘要：
The present invention is concerned with isoxazol-4-yl-oxadiazole derivatives of formula wherein R1, R2, and R3, are as defined in the specification and pharmaceutically acceptable acid addition salts thereof. This class of compounds has high affinity and selectivity for GABA A α5 receptor binding sites and might be useful as cognitive enhancer or for the treatment of cognitive disorders like Alzheimer's disease.
公开/授权文献
- US20070161686A1 Aryl-isoxazolo-4-yl-oxadiazole derivatives 公开/授权日：2007-07-12
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