发明授权
- 专利标题： Pyrimidine derivatives useful as inhibitors of PKC-theta
- 专利标题（中）： 可用作PKC-θ抑制剂的嘧啶衍生物
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申请号： US10933635申请日： 2004-09-03
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公开(公告)号： US07550473B2公开(公告)日： 2009-06-23
- 发明人: Mario G. Cardozo , Derek Cogan , Charles Lawrence Cywin , George Dahmann , Darren DiSalvo , John David Ginn , Anthony S. Prokopowicz, III , Denice M. Spero , Erick Richard Roush Young
- 申请人： Mario G. Cardozo , Derek Cogan , Charles Lawrence Cywin , George Dahmann , Darren DiSalvo , John David Ginn , Anthony S. Prokopowicz, III , Denice M. Spero , Erick Richard Roush Young
- 申请人地址： US CT Ridgefield DE Ingelheim
- 专利权人： Boehringer Ingelheim Pharmaceuticals, Inc.,Boehringer Ingelheim Pharma GmbH & Co. KG
- 当前专利权人： Boehringer Ingelheim Pharmaceuticals, Inc.,Boehringer Ingelheim Pharma GmbH & Co. KG
- 当前专利权人地址： US CT Ridgefield DE Ingelheim
- 代理商 Michael P. Morris; Mary-Ellen M. Devlin; Philip I. Datlow
- 主分类号： C07D239/42
- IPC分类号： C07D239/42 ; A61K31/505
摘要：
Disclosed are novel compounds of formula (I): wherein R1, R2 and R3 are as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC-theta, including immunological disorders and type II diabetes. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
公开/授权文献
- US20050124640A1 Pyrimidine derivatives useful as inhibitors of PKC-theta 公开/授权日：2005-06-09
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