发明授权
- 专利标题： 4-phenylpiperdine-pyrazole CCR1 antagonists
- 专利标题（中）： 4-苯基哌啶 - 吡唑CCR1拮抗剂
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申请号： US11546938申请日： 2006-10-11
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公开(公告)号： US07576218B2公开(公告)日： 2009-08-18
- 发明人: Penglie Zhang , Andrew M. K. Pennell , Wei Chen , Kevin Lloyd Greenman , Lianfa Li , Edward J. Sullivan , Valeri V. Martichonok
- 申请人： Penglie Zhang , Andrew M. K. Pennell , Wei Chen , Kevin Lloyd Greenman , Lianfa Li , Edward J. Sullivan , Valeri V. Martichonok
- 申请人地址： US CA Mountain View
- 专利权人： ChemoCentryx, Inc.
- 当前专利权人： ChemoCentryx, Inc.
- 当前专利权人地址： US CA Mountain View
- 代理机构： Townsend and Townsend and Crew LLP
- 主分类号： C07D401/06
- IPC分类号： C07D401/06 ; A61K31/454
摘要：
Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally monocyclic and bicyclic compounds and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
公开/授权文献
- US20070088036A1 Piperidine derivatives and methods of use 公开/授权日：2007-04-19
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