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公开(公告)号：US07576218B2
公开(公告)日：2009-08-18
申请号：US11546938
申请日：2006-10-11
申请人： Penglie Zhang , Andrew M. K. Pennell , Wei Chen , Kevin Lloyd Greenman , Lianfa Li , Edward J. Sullivan , Valeri V. Martichonok
发明人： Penglie Zhang , Andrew M. K. Pennell , Wei Chen , Kevin Lloyd Greenman , Lianfa Li , Edward J. Sullivan , Valeri V. Martichonok
IPC分类号： C07D401/06 , A61K31/454
CPC分类号： C07D401/06 , C07D211/42 , C07D211/52 , C07D211/56 , C07D211/60 , C07D211/64 , C07D401/14 , C07D413/14 , C07D471/04
摘要： Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally monocyclic and bicyclic compounds and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
摘要翻译： 提供了作为CCR1受体的有效拮抗剂并具有体内抗炎活性的化合物。 化合物通常是单环和双环化合物，并且可用于药物组合物，用于治疗CCR1介导的疾病的方法，以及用于鉴定竞争性CCR1拮抗剂的测定中的对照。
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公开(公告)号：US07576106B2
公开(公告)日：2009-08-18
申请号：US11580202
申请日：2006-10-11
申请人： Penglie Zhang , Andrew M. K. Pennell , Wei Chen , Kevin Lloyd Greenman , Edward J. Sullivan , Lianfa Li
发明人： Penglie Zhang , Andrew M. K. Pennell , Wei Chen , Kevin Lloyd Greenman , Edward J. Sullivan , Lianfa Li
IPC分类号： C07D401/06 , A61K31/454
CPC分类号： C07D401/06 , C07D211/42 , C07D211/52 , C07D211/56 , C07D211/60 , C07D211/64 , C07D401/14 , C07D413/14 , C07D471/04
摘要： Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally monocyclic and bicyclic compounds and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
摘要翻译： 提供了作为CCR1受体的有效拮抗剂并具有体内抗炎活性的化合物。 化合物通常是单环和双环化合物，并且可用于药物组合物，用于治疗CCR1介导的疾病的方法，以及用于鉴定竞争性CCR1拮抗剂的测定中的对照。
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公开(公告)号：US07790726B2
公开(公告)日：2010-09-07
申请号：US11504215
申请日：2006-08-14
申请人： Penglie Zhang , Andrew M. K. Pennell , John J. Kim Wright , Lianfa Li , Edward J. Sullivan , Wei Chen , Kevin Lloyd Greenman
发明人： Penglie Zhang , Andrew M. K. Pennell , John J. Kim Wright , Lianfa Li , Edward J. Sullivan , Wei Chen , Kevin Lloyd Greenman
IPC分类号： C07D263/58 , C07D413/06 , A61K31/496 , C07D401/06 , C07D498/04
CPC分类号： C07D413/06 , C07D231/56 , C07D233/36 , C07D235/26 , C07D263/22 , C07D263/58 , C07D265/18 , C07D295/185 , C07D401/06 , C07D413/04 , C07D471/04
摘要： Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally monocyclic and bicyclic compounds and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
摘要翻译： 提供了作为CCR1受体的有效拮抗剂并具有体内抗炎活性的化合物。 化合物通常是单环和双环化合物，并且可用于药物组合物，用于治疗CCR1介导的疾病的方法，以及用于鉴定竞争性CCR1拮抗剂的测定中的对照。
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公开(公告)号：US07777035B2
公开(公告)日：2010-08-17
申请号：US11752201
申请日：2007-05-22
申请人： Penglie Zhang , Andrew M. K. Pennell , John J. Kim Wright , Wei Chen , Manmohan R. Leleti , Yandong Li , Lianfa Li , Yuan Xu , Mark M. Gleason , Yibin Zeng , Kevin Lloyd Greenman
发明人： Penglie Zhang , Andrew M. K. Pennell , John J. Kim Wright , Wei Chen , Manmohan R. Leleti , Yandong Li , Lianfa Li , Yuan Xu , Mark M. Gleason , Yibin Zeng , Kevin Lloyd Greenman
IPC分类号： C07D471/04
CPC分类号： A61K31/496 , A61K31/5377 , A61K45/06 , C07D471/04 , C07D487/04
摘要： Methods are provided for the synthesis of 1-[4-(substituted phenyl)-piperazin-1-yl ] -2- [3-(1H-imidazol-2-yl)-pyrazolo [3,4-b]pyridin-1-yl]-ethanone compounds via construction of the imidazole portion onto the corresponding aldehyde or nitrile compounds.
摘要翻译： 提供了合成1- [4-（取代的苯基） - 哌嗪-1-基] -2- [3-（1H-咪唑-2-基） - 吡唑并[3,4-b]吡啶-1 - 基] - 乙酮化合物通过将咪唑部分构建到相应的醛或腈化合物上。
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公开(公告)号：US07524845B2
公开(公告)日：2009-04-28
申请号：US11474132
申请日：2006-06-22
申请人： Penglie Zhang , Andrew M. K. Pennell , John J. Kim Wright , Wei Chen , Manmohan R. Leleti , Yandong Li , Lianfa Li , Yuan Xu
发明人： Penglie Zhang , Andrew M. K. Pennell , John J. Kim Wright , Wei Chen , Manmohan R. Leleti , Yandong Li , Lianfa Li , Yuan Xu
IPC分类号： A61K31/5377 , A61K31/496 , C07D471/04 , C07D487/04
CPC分类号： C07D487/04 , C07D471/04
摘要： Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
摘要翻译： 提供了作为CCR1受体的有效拮抗剂并具有体内抗炎活性的化合物。 化合物通常为芳基哌嗪衍生物，并且可用于药物组合物，用于治疗CCR1介导的疾病的方法，以及用于鉴定竞争性CCR1拮抗剂的测定中的对照。
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公开(公告)号：US20130338157A1
公开(公告)日：2013-12-19
申请号：US13774938
申请日：2013-02-22
申请人： Penglie Zhang , Andrew M.K. Pennell , John J. Kim Wright , Wei Chen , Manmohan R. Leleti , Yandong Li , Lianfa Li , Yuan Xu , Mark M. Gleason , Yibin Zeng , Kevin Lloyd Greenman
发明人： Penglie Zhang , Andrew M.K. Pennell , John J. Kim Wright , Wei Chen , Manmohan R. Leleti , Yandong Li , Lianfa Li , Yuan Xu , Mark M. Gleason , Yibin Zeng , Kevin Lloyd Greenman
IPC分类号： C07D471/04 , C07D487/04
CPC分类号： A61K31/496 , A61K31/5377 , A61K45/06 , C07D471/04 , C07D487/04
摘要： Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
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公开(公告)号：US20110098308A1
公开(公告)日：2011-04-28
申请号：US12829312
申请日：2010-07-01
申请人： Penglie Zhang , Andrew M.K. Pennell , John J. Kim Wright , Wei Chen , Manmohan R. Leleti , Yandong Li , Lianfa Li , Yuan Xu , Mark M. Gleason , Yibin Zeng , Kevin Lloyd Greenman
发明人： Penglie Zhang , Andrew M.K. Pennell , John J. Kim Wright , Wei Chen , Manmohan R. Leleti , Yandong Li , Lianfa Li , Yuan Xu , Mark M. Gleason , Yibin Zeng , Kevin Lloyd Greenman
IPC分类号： A61K31/497 , C07D471/04 , A61P19/02 , A61P25/00 , A61P17/00 , A61P1/00 , A61P37/08 , A61P25/16 , A61P25/28
CPC分类号： A61K31/496 , A61K31/5377 , A61K45/06 , C07D471/04 , C07D487/04
摘要： Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
摘要翻译： 提供了作为CCR1受体的有效拮抗剂并具有体内抗炎活性的化合物。 化合物通常为芳基哌嗪衍生物，并且可用于药物组合物，用于治疗CCR1介导的疾病的方法，以及用于鉴定竞争性CCR1拮抗剂的测定中的对照。
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公开(公告)号：US20070066583A1
公开(公告)日：2007-03-22
申请号：US11504215
申请日：2006-08-14
申请人： Penglie Zhang , Andrew Pennell , John J. Wright , Lianfa Li , Edward Sullivan , Wei Chen , Kevin Lloyd Greenman
发明人： Penglie Zhang , Andrew Pennell , John J. Wright , Lianfa Li , Edward Sullivan , Wei Chen , Kevin Lloyd Greenman
IPC分类号： A61K31/55 , A61K31/506 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/454 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D413/06 , C07D231/56 , C07D233/36 , C07D235/26 , C07D263/22 , C07D263/58 , C07D265/18 , C07D295/185 , C07D401/06 , C07D413/04 , C07D471/04
摘要： Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally monocyclic and bicyclic compounds and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
摘要翻译： 提供了作为CCR1受体的有效拮抗剂并具有体内抗炎活性的化合物。 化合物通常是单环和双环化合物，并且可用于药物组合物，用于治疗CCR1介导的疾病的方法，以及用于鉴定竞争性CCR1拮抗剂的测定中的对照。
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公开(公告)号：US08383630B2
公开(公告)日：2013-02-26
申请号：US12829312
申请日：2010-07-01
申请人： Penglie Zhang , Andrew M. K. Pennell , John J. Kim Wright , Wei Chen , Manmohan R. Leleti , Yandong Li , Lianfa Li , Yuan Xu
发明人： Penglie Zhang , Andrew M. K. Pennell , John J. Kim Wright , Wei Chen , Manmohan R. Leleti , Yandong Li , Lianfa Li , Yuan Xu
IPC分类号： A61K31/437 , A61P19/02
CPC分类号： A61K31/496 , A61K31/5377 , A61K45/06 , C07D471/04 , C07D487/04
摘要： Provided are methods for the treatment of rheumatoid arthritis using compounds of formula Ia and Ib: or a pharmaceutically acceptable salt, hydrate or N-oxide thereof.
摘要翻译： 提供了使用式Ia和Ib化合物或其药学上可接受的盐，水合物或N-氧化物治疗类风湿性关节炎的方法。
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公开(公告)号：US07589199B2
公开(公告)日：2009-09-15
申请号：US11008774
申请日：2004-12-08
申请人： Andrew M. K. Pennell , James B. Aggen , J. J. Kim Wright , Subhabrata Sen , Brian E. McMaster , Daniel Joseph Dairaghi , Wei Chen , Penglie Zhang
发明人： Andrew M. K. Pennell , James B. Aggen , J. J. Kim Wright , Subhabrata Sen , Brian E. McMaster , Daniel Joseph Dairaghi , Wei Chen , Penglie Zhang
IPC分类号： A61K31/496 , C07D401/14 , C07D403/14
CPC分类号： C07D403/04 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/52 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/18 , C07D231/38 , C07D231/56 , C07D233/61 , C07D235/06 , C07D235/16 , C07D249/08 , C07D249/14 , C07D257/04 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/04 , C07D407/04 , C07D409/04 , C07D413/04 , C07D413/12 , C07D417/04 , C07D471/04 , C07D473/34 , A61K2300/00
摘要： Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
摘要翻译： 提供了作为CCR1受体的有效拮抗剂并具有体内抗炎活性的化合物。 化合物通常为芳基哌嗪衍生物，并且可用于药物组合物，用于治疗CCR1介导的疾病的方法，以及用于鉴定竞争性CCR1拮抗剂的测定中的对照。
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