Invention Grant
- Patent Title: Acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same
- Patent Title (中): 无环核苷膦酸衍生物,其盐及其制备方法
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Application No.: US11455679Application Date: 2006-06-20
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Publication No.: US07605147B2Publication Date: 2009-10-20
- Inventor: Dong-Gyu Cho , Jae-Hong Lim , Jae-Taeg Hwang , Woo-Young Cho , Hyun-Sook Jang , Chang-Ho Lee , Tae-Saeng Choi , Chung-Mi Kim , Yong-Zu Kim , Tae-Kyun Kim , Seung-Joo Cho , Gyoung-Won Kim , Jong-Ryoo Choi , Jeong-Min Kim , Kee-Yoon Roh
- Applicant: Dong-Gyu Cho , Jae-Hong Lim , Jae-Taeg Hwang , Woo-Young Cho , Hyun-Sook Jang , Chang-Ho Lee , Tae-Saeng Choi , Chung-Mi Kim , Yong-Zu Kim , Tae-Kyun Kim , Seung-Joo Cho , Gyoung-Won Kim , Jong-Ryoo Choi , Jeong-Min Kim , Kee-Yoon Roh
- Applicant Address: KR Seoul
- Assignee: LG Life Sciences Ltd.
- Current Assignee: LG Life Sciences Ltd.
- Current Assignee Address: KR Seoul
- Agency: Birch, Stewart, Kolasch, Birch, LLP
- Priority: KR2001-3087 20010119
- Main IPC: C07F9/6561
- IPC: C07F9/6561 ; A61K31/675 ; A61P31/20 ; C07F9/6512 ; C07F9/40 ; C07F7/18

Abstract:
The present invention relates to an acyclic nucleoside phosphonate derivative represented by the following formula (1): in which represents single bond or double bond, R1, R2, R3, R7 and R8 are defined herein, Y represents —O—, —S—, —CH(Z)-, ═C(Z)-, —N(Z)-, ═N—, or —SiH(Z)-, wherein Z represents hydrogen, hydroxy or halogen, or represents C1-C7-alkyl, C1-C5-alkoxy, allyl, hydroxy-C1-C7-alkyl, C1-C7-aminoalkyl or phenyl, Q represents a group having the following formula: wherein X1, and X2 independently of one another represent hydrogen, amino, hydroxy or halogen, or represent C1-C7-alkyl, C1-C5-alkoxy, allyl, hydroxy-C1-C7-alkyl, phenyl or phenoxy each of which is optionally substituted by nitro or C1-C5-alkoxy, or represent C6-C10-arylthio which is optionally substituted by nitro, amino, C1-C6-alkyl or C1-C4-alkoxy, or represent C6-C12-arylamino, C1-C7-alkylamino, di(C1-C7-alkyl)amino, C3-C6-cycloalkylamino or a structure of wherein n denotes an integer of 1 or 2 and Y1 represents O, CH2 or N—R (R represents C1-C7-alkyl or C6-C12-aryl), which is useful as an antiviral agent (particularly, against hepatitis B virus), pharmaceutically acceptable salts, stereoisomers, and a process for the preparation thereof.
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