发明授权
- 专利标题： Stat3 antagonists and their use as vaccines against cancer
- 专利标题（中）： Stat3拮抗剂及其作为疫苗的用途
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申请号： US10383707申请日： 2003-03-07
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公开(公告)号： US07638122B2公开(公告)日： 2009-12-29
- 发明人: Hua Yu , Drew Pardoll , Richard Jove
- 申请人： Hua Yu , Drew Pardoll , Richard Jove
- 申请人地址： US FL Tampa US MD Baltimore
- 专利权人： University of South Florida,Johns Hopkins University
- 当前专利权人： University of South Florida,Johns Hopkins University
- 当前专利权人地址： US FL Tampa US MD Baltimore
- 代理机构： Fish & Richardson P.C.
- 主分类号： A61K35/12
- IPC分类号： A61K35/12 ; A61K35/14 ; A61K41/00
摘要：
The present invention relates to methods for treating and/or preventing cancer. In particular the present invention relates to ex vivo immunotherapeutic methods. The methods comprise decreasing Stat3 (signal transducer and activator of transcription3) expression and/or function in tumor cells and the administration of such cells to a subject in need of treatment and/or prevention. Other methods of the invention comprise activating T-cells by co-culturing the T-cells with the tumor cells with decreased Stat3 expression or function. The invention further encompasses methods comprising decreasing Stat3 expression or function in antigen-presenting cells and co-administering tumor cells and the antigen-presenting cells with decreased Stat3 function to a patient. The invention further relates to methods for stimulating dendritic cell differentiation.
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