Avermectin and avermectin monosaccharaide compounds, derivatives, and compositions thereof are provided as well as processes for preparing such compounds, derivatives, and compositions. Intermediates in the preparation of avermectin and avermectin monosaccharaide derivatives and methods of controlling pests are also provided. The avermectin and avermectin monosaccharaide derivatives are demonstrated as useful in controlling pests, in particular pests that are harmful to crop plants and to its propagation materials, such as representatives of the class insecta, the order Acarina and the class nematede.