Invention Grant
US07777017B2 Nucleic acids encoding opsonic monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria
有权
编码针对革兰氏阳性菌的脂磷壁酸特异性的调理单克隆和嵌合抗体的核酸
- Patent Title: Nucleic acids encoding opsonic monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria
- Patent Title (中): 编码针对革兰氏阳性菌的脂磷壁酸特异性的调理单克隆和嵌合抗体的核酸
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Application No.: US11724040Application Date: 2007-03-13
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Publication No.: US07777017B2Publication Date: 2010-08-17
- Inventor: Jeffrey R. Stinson , Richard F. Schuman , James Jacob Mond , Andrew Lees , Gerald Walter Fischer
- Applicant: Jeffrey R. Stinson , Richard F. Schuman , James Jacob Mond , Andrew Lees , Gerald Walter Fischer
- Applicant Address: US MD Gaithersburg
- Assignee: Biosynexus Incorporated
- Current Assignee: Biosynexus Incorporated
- Current Assignee Address: US MD Gaithersburg
- Agency: Lahive & Cockfield, LLP
- Agent Amy E. Mandragouras, Esq.
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12N5/06 ; C12N15/00 ; A61K39/395 ; C12P21/04 ; C12P21/08 ; C07K16/00
Abstract:
The present invention encompasses monoclonal antibodies that bind to lipoteichoic acid (LTA) of Gram positive bacteria. The antibodies also bind to whole bacteria and enhance phagocytosis and killing of the bacteria in vitro. The invention also provides antibodies having human sequences (chimeric, humanized and human antibodies). The invention also sets forth the variable regions of three antibodies within the invention and presents the striking homology between them.
Public/Granted literature
- US20080019976A1 Opsonic monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria Public/Granted day:2008-01-24
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